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PGAM1 Recombinant Monoclonal Antibody

  • 中文名稱：
    PGAM1重組抗體
  • 貨號：
    CSB-RA935337A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, Mouse Brain whole cell lysate, Rat Brain whole cell lysate
      All lanes: PGAM1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 29 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA935337A0HU PGAM1重組單克隆抗體是針對磷酸甘油酸變位酶1（PGAM1）開發(fā)的高特異性科研試劑。該靶標作為糖酵解通路關(guān)鍵酶，在細胞能量代謝和生物合成過程中發(fā)揮重要作用，其表達異常與多種病理過程密切相關(guān)。本產(chǎn)品采用重組技術(shù)制備，經(jīng)嚴格驗證可在Western Blot實驗中穩(wěn)定識別天然及重組PGAM1蛋白，檢測結(jié)果呈現(xiàn)清晰單一條帶，推薦使用稀釋范圍為1:500至1:5000，同時適用于ELISA平臺檢測。其高靈敏度和低背景特性使其成為研究腫瘤代謝重編程、細胞增殖調(diào)控以及氧化應(yīng)激機制的有效工具，特別適用于體外培養(yǎng)細胞模型的蛋白表達分析、代謝通路研究及相關(guān)小分子抑制劑的藥效評價等基礎(chǔ)科研領(lǐng)域。該抗體具備優(yōu)異的批次間穩(wěn)定性，為科研工作者探索PGAM1在疾病發(fā)生發(fā)展中的分子機制提供可靠保障。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B), PGAM1, PGAMA
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide derived from human PGAM1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9A5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
  • 基因功能參考文獻：
    1. High PGAM1 expression is associated with Pancreatic Ductal Adenocarcinoma Metastasis. PMID: 29386088
    2. conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1 PMID: 28748916
    3. When BPGM is knocked out, 1,3-BPG can directly phosphorylate PGAM1. In this case, PGAM1 phosphorylation and activity are decreased, but nevertheless sufficient to maintain normal glycolytic flux and cellular growth rate. PMID: 28805803
    4. study provided the first evidence revealing a non-metabolic function of PGAM1 in promoting cell migration, and gained new insights into the role of PGAM1 in cancer progression. PMID: 27991922
    5. Data show that tyrosine 26 phosphorylation enhances the binding of phosphoglycerate mutase 1 (PGAM1) to its substrates through generating electrostatic environment and structural features that are advantageous to the binding. PMID: 28076845
    6. PGAM1 in promoting homologous recombination repair in tumor cell lines. Suggest potential therapeutic opportunity for PGAM1 inhibitors in combination with PARP inhibitors in cancer treatment. PMID: 28122957
    7. PGAM1 may be associated with the grade of glioma and be involved in the biological behavior of glioma cells. PGAM1 might be a novel therapeutic target in glioma. PMID: 27572934
    8. PGAM1 correlates with spermatogenic dysfunction and affects the function of cell proliferation, apoptosis and migration. PMID: 25701843
    9. Our finding showed that PGAM1 might serve as a promising therapeutic target for UBC. PMID: 26655504
    10. PGAM1 is highly expressed in clear cell renal cell carcinoma and correlated with clinicalpathological features, which may contribute to tumor formation and progression. PMID: 26464696
    11. PGAM is acetylated at lysines 100/106/113/138 in its central region, and a member of the Sirtuin family (class III deacetylase), SIRT2, is responsible for its deacetylation. PMID: 25195573
    12. Tyrosine26 phosphorylation represents an additional acute mechanism underlying phosphoglycerate mutase 1 upregulation. PMID: 23653202
    13. Phosphoglycerate mutase 1 (PGAM1) contributes to biosynthesis regulation by controlling intracellular levels of its substrate, 3-phosphoglycerate (3-PG), and product, 2-phosphoglycerate (2-PG). PMID: 23153533
    14. PGAM1 deacetylation and activity are directly controlled by Sirt1. PMID: 22157007
    15. histidine-phosphorylated PGAM1 correlated with expression of PKM2 in cancer cell lines; decreased pyruvate kinase activity in PKM2-expressing cells allows PEP-dependent histidine phosphorylation of PGAM1 and may provide an alternate glycolytic pathway PMID: 20847263
    16. Our studies suggested that PGAM1 plays an important role in hepatocarcinogenesis PMID: 20403181
    17. Results identified phosphoglycerate mutase 1 that showed elevated levels of protein carbonyls in inferior parietal lobule (IPL) from subjects with early stage-Alzheimer's disease. PMID: 19686046
    18. Cloning, purification, crystallization and preliminary crystallographic analysis of human phosphoglycerate mutase PMID: 15388943
    19. Phosphoglycerate mutase may have a role in preventing non-spherocytic anemia [case report] PMID: 15710582
    20. We report two patients in whom phosphoglycerate mutase (PGAM) deficiency was associated with the triad of exercise-induced cramps, recurrent myoglobinuria, and tubular aggregates in the muscle biopsy. PMID: 16881065

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  • 蛋白家族：
    Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
  • 組織特異性：
    Expressed in the liver and brain. Not found in the muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8888

    OMIM: 172250

    KEGG: hsa:5223

    STRING: 9606.ENSP00000359991

    UniGene: Hs.632918