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  4. STAT6 Recombinant Monoclonal Antibody

STAT6 Recombinant Monoclonal Antibody

  • 中文名稱：
    STAT6重組抗體
  • 貨號：
    CSB-RA988543A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate
      All lanes: STAT6 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 95, 75, 82 kDa
      Observed band size: 100 kDa
    • IHC image of CSB-RA988543A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    STAT6重組單克隆抗體（產(chǎn)品號：CSB-RA988543A0HU）是針對信號轉(zhuǎn)導與轉(zhuǎn)錄激活因子6（STAT6）開發(fā)的高特異性科研工具。STAT6作為IL-4/IL-13信號通路的核心介質(zhì)，在免疫調(diào)控、細胞增殖及炎癥反應中發(fā)揮關(guān)鍵作用，尤其在Th2細胞分化和過敏性疾病相關(guān)機制研究中具有重要價值。本產(chǎn)品經(jīng)ELISA、Western Blot（WB）和免疫組化（IHC）多平臺驗證，在WB實驗中可精準識別內(nèi)源性STAT6蛋白，推薦稀釋梯度為1:500-1:5000，顯影背景低且信號清晰；IHC應用顯示其在石蠟包埋組織切片中具有優(yōu)異的抗原定位能力，推薦使用濃度1:50-1:200。其重組單克隆特性確保了批次間穩(wěn)定性和高親和力，適用于分析STAT6在細胞信號轉(zhuǎn)導、腫瘤微環(huán)境調(diào)控及免疫代謝研究中的表達與功能，為探索呼吸道炎癥、腫瘤免疫逃逸等領(lǐng)域的分子機制提供可靠支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Signal transducer and activator of transcription 6 (IL-4 Stat), STAT6
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide derived from human STAT6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2F10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Carries out a dual signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
  • 基因功能參考文獻：
    1. is a dependable marker to differentiate solitary fibrous tumors and myofibromas PMID: 28689369
    2. Inhibition of STAT6/Anoctamin-1 activation decreased proliferation, migration, or invasion of gastric cancer cells. PMID: 29466035
    3. Results of our structure-function studies on STAT6 shed light on mechanism of DNA recognition by STATs in general and explain the reasons underlying STAT6's preference for N4 site DNA over N3. PMID: 27803324
    4. There was no significant relationship between rs324011 and rs3024974 SNPs and psoriasis in the present study or in other studies, indicating that STAT6 is not a candidate gene for psoriasis susceptibility PMID: 28420002
    5. these results showed that allergy responses further accelerated the IL-4-induced inhibition of tumor development through the activation of STAT6 pathways. PMID: 28587956
    6. In this study, significant lower level of miR-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR. PMID: 28752100
    7. IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells PMID: 27533463
    8. N4 DNA recognition by STAT6: structural and functional implications. PMID: 28220394
    9. Data suggest that STAT6 and RANKL are involved in regulation of apoptosis, gene expression, and cell proliferation in hepatocellular carcinoma cell lines; depletion of STAT6 using RNA interference increases apoptosis; this mechanism involves down-regulation of expression of RANKL. (STAT6 = signal transducer and activator of transcription 6; RANKL = receptor activator of nuclear factor kappa B ligand) PMID: 28525794
    10. The results showed that SARS coronavirus papain-like protease (PLPro) stimulated TGF-beta1-dependent expression of Type I collagen via activating STAT6 pathway. PMID: 28414040
    11. High STAT6 expression is associated with melanoma. PMID: 26993600
    12. Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations. PMID: 26965583
    13. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3. PMID: 27737800
    14. The results suggest that nuclear localization and cleavage of STAT6 is important for modulating the viral latency and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). PMID: 28099521
    15. PVT1-derived miR-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6. PMID: 28235236
    16. STAT6 single-nucleotide polymorphism is associated with migraine. PMID: 27322543
    17. STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice. PMID: 27906181
    18. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours. PMID: 28072477
    19. STAT6 and ALDH1 immunohistochemistry can be used in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms. PMID: 27068523
    20. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor PMID: 26927892
    21. STAT6-TMEM16A-ERK1/2 signal pathway and TMEM16A channel activity are required for the IL-13-induced TMEM16A mediated mucus production PMID: 27588910
    22. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics. PMID: 24702701
    23. The role of Th2 cytokines (IL-4, IL-13) and STAT6 in Th1/Th2 imbalance. PMID: 26781462
    24. STAT6 gene (G2964) polymorphism may play a role in development of eczema among Saudi children PMID: 27018548
    25. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges. PMID: 27271270
    26. It is a diagnostic tumor marker for Papillary' solitary fibrous tumor/hemangiopericytoma. PMID: 26746203
    27. nuclear immunohistochemistry staining can be used as a diagnostic criteria for unconventional fat-forming solitary fibrous tumors PMID: 25517867
    28. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type. PMID: 26686340
    29. Case Report: NAB2-STAT6 fusion in glioblastoma. PMID: 26817999
    30. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct dendritic-cell-specific functional DNA methylation changes PMID: 26758199
    31. interleukin-4 regulates hematopoietic lineage choice by activating the JAK3-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation PMID: 26829670
    32. Immunohistochemistry results indicate that combination with ALDH1 and STAT6 can improve the diagnostic value of CD34 for solitary fibrous tumors. PMID: 26617768
    33. T allele of rs324011 in STAT6 would increase the risk of atopic dermatitis (AD) occurrence in children. Haplotypes of rs324011/rs167769 were also significantly associated with childhood AD in Taiwanese population. PMID: 26048407
    34. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors PMID: 26226844
    35. STAT6 is a direct target of miR-361-5p and promotes Bcl-xL expression. PMID: 26461141
    36. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts. PMID: 26883114
    37. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites. PMID: 25893823
    38. bovine milk activates STAT6 in a p44/42 and p38-dependent manner in skin cells PMID: 26134630
    39. IL13Ralpha2 knockdown and IL-13 treatment cooperatively upregulated the metastasis suppressor tumor protein 63 (TP63) in a STAT6-dependent manner. PMID: 26208975
    40. Igepsilon gene transcription is regulated by histone modifications in the IL-4/STAT6 pathway. PMID: 25952120
    41. Solitary fibrous tumor occurring in the ocular adnexa (OA) as orbital mass with proptosis. In the OA, solitary fibrous tumor demonstrates STAT6 nuclear expression. PMID: 25761539
    42. Immunostaining and semiquantitative analysis revealed increased presence of phosphor-STAT6 in the pulmonary vasculature of patients with connective tissue disease-associated PAH and Schistosoma-PAH compared with normal control subjects. PMID: 26192556
    43. IL-13/STAT6 signaling is modulated by Kaposi's sarcoma-associated herpesvirus to promote host cell proliferation and viral pathogenesis. PMID: 26246572
    44. Eosinophilic esophagitis was associate with increased expression of STAT6. PMID: 25407941
    45. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features. PMID: 25554652
    46. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17 PMID: 26136329
    47. results show that Cbl-b suppresses human ORMDL3 expression through STAT6 PMID: 26112603
    48. TRAIL induces RANKL expression through a STAT-6 dependent transcriptional regulatory mechanism in bone marrow stromal/preosteoblast cells. PMID: 25445452
    49. Strong nuclear STAT6 is largely specific for solitary fibrous tumors (SFTs). Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance. PMID: 25873501
    50. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201). PMID: 25582503

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
  • 蛋白家族：
    Transcription factor STAT family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11368

    OMIM: 601512

    KEGG: hsa:6778

    STRING: 9606.ENSP00000300134

    UniGene: Hs.524518