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  4. Recombinant Danio rerio Hepatocyte nuclear factor 1-beta-A (hnf1ba), partial

Recombinant Danio rerio Hepatocyte nuclear factor 1-beta-A (hnf1ba), partial

  • 中文名稱：
    斑馬魚hnf1ba重組蛋白
  • 貨號：
    CSB-YP374598DIL
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    斑馬魚hnf1ba重組蛋白
  • 貨號：
    CSB-EP374598DIL
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    斑馬魚hnf1ba重組蛋白
  • 貨號：
    CSB-EP374598DIL-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    斑馬魚hnf1ba重組蛋白
  • 貨號：
    CSB-BP374598DIL
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    斑馬魚hnf1ba重組蛋白
  • 貨號：
    CSB-MP374598DIL
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    hnf1ba
  • Uniprot No.：
  • 別名：
    hnf1ba; hnf1b; tcf2; Hepatocyte nuclear factor 1-beta-A; HNF-1-beta-A; HNF-1B-A; Hepatocyte nuclear factor 1-beta-2; HNF-1B-2; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Required for induction of rhombomere r5/r6 gene expression in the hindbrain.
  • 基因功能參考文獻：
    1. Data show that hnf1ba generates a permissive domain for Wnt signaling activity in the foregut endoderm PMID: 23720049
    2. essential for normal segmentation of nephrons during kidney organogenesis PMID: 23160512
    3. Knockdown of pk1a led to decreased expression of vhnf1, a homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation; forced expression of vhnf1 mRNA led to rescue of the pk1a morphant phenotype PMID: 21215262
    4. Data show that vhnf1 functions in two ways to subdivide the zebrafish caudal hindbrain domain (r4-r7) into individual rhombomeres. PMID: 12835397
    5. Zebrafish tcf2 gene, composed of 9 exons, was mapped to linkage group LG15. PMID: 15302404
    6. vhnf1 acts largely independently of val to repress the rhombomere 4 'hox code' posterior to the rhombomere 4-5 boundary PMID: 15342476
    7. Vhnf1 expression within the posterior neural tube (up to r5) promotes posterior and dorsal fates in the otic vesicle, at the expense of anterior and ventral fates. PMID: 17137573
    8. investigated the signaling pathways that regulate vhnf1 expression during pancreas development PMID: 17217944
    9. Data show that zebrafish mutants for Tcf2 fail to specify a single lumen in their gut tube and instead develop multiple lumens, and show that Tcf2 controls single lumen formation by regulating claudin15 and Na+/K+-ATPase expression. PMID: 17632505
    10. vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification. PMID: 18635606
    11. It was concluded that hnf1b(hi2169) is hypomorphic to hnf1b(hi1843) and that, while hnf1b is required for r5/r6 gene expression in the hindbrain, r5/r6 gene expression can be experimentally induced independently of hnf1b anterior to the hindbrain. PMID: 18945197

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    HNF1 homeobox family
  • 組織特異性：
    During embryonic development, expressed dynamically in the developing hindbrain, kidney (pronephros), gut, liver and pancreas; expressed in both intermediate mesoderm (precursor to the kidney) and the caudal hindbrain (including rhombomeres r5 and r6) at
  • 數據庫鏈接：