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  4. Recombinant Drosophila melanogaster Nuclear hormone receptor FTZ-F1 (ftz-f1), partial

Recombinant Drosophila melanogaster Nuclear hormone receptor FTZ-F1 (ftz-f1), partial

  • 中文名稱：
    黑腹果蠅ftz-f1重組蛋白
  • 貨號：
    CSB-YP339334DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅ftz-f1重組蛋白
  • 貨號：
    CSB-EP339334DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅ftz-f1重組蛋白
  • 貨號：
    CSB-EP339334DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅ftz-f1重組蛋白
  • 貨號：
    CSB-BP339334DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅ftz-f1重組蛋白
  • 貨號：
    CSB-MP339334DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ftz-f1
  • Uniprot No.：
  • 別名：
    ftz-f1; NR5A3; CG4059Nuclear hormone receptor FTZ-F1; FTZ-F1 alpha; Nuclear receptor subfamily 5 group A member 3
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

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靶點詳情

  • 功能：
    Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
  • 基因功能參考文獻：
    1. the alpha6 helix is dynamic in solution when Ftz-F1 is bound to the LxxLL motif of its cofactor Ftz, undergoing motions on the fast (picosecond to nanosecond) as well as slow (microsecond to millisecond) time scales. PMID: 29547262
    2. a novel ecdysone-dependent enhancer in the intron of ftz-f1 gene PMID: 28726107
    3. Comparative analysis of enhancers containing Ftz/Ftz-F1 binding sites that were or were not bona fide targets in vivo suggested that GAF negatively regulates enhancers that contain Ftz/Ftz-F1 binding sites but are not actually utilized. PMID: 27723822
    4. dATAC histone acetyltransferase complex is indispensable for the regulation of expression and probably for the stabilization of Ftz-F1, the main transcription regulator of Halloween genes. PMID: 25959239
    5. betaFTZ-F1 is expressed in most cells at the late pupal stage, under the control of ecdysteroids and plays important roles during pupal development. PMID: 24611773
    6. functional equivalence of ftz-f1 orthologs in these sensitive in vivo assays argues against specific activating ligands for NR5A family members PMID: 23340581
    7. ssFTZ-F1 is required for fat-body remodeling in Drosophila PMID: 21978772
    8. betaFTZ-F1 is a regulator for temporal gene expression at the onset of metamorphosis PMID: 12392575
    9. betaFTZ-F1 plays a role in regulating ecdysteroid titers during post-embryonic developmentby regulating Phantom protein and Disembodied protein expression. PMID: 15936331
    10. EDG84A gene encoding pupal cuticle protein is one of the targets of ecdysteroid-inducible transcription factor betaFTZ-F1; betaFTZ-F1 is expressed in almost all tissues. PMID: 16025347
    11. Serves as a molecular sign to guide the recruitment of ecdysone receptor/Ultraspiracle/FISC to 20-hydroxyecdysone-inducible target promoters. PMID: 17015464
    12. propose that pair-rule genes, exemplified by Ftz/Ftz-F1, promote segmentation by acting at different hierarchical levels, regulating segmentation and regulatory genes PMID: 19679121
    13. The Ftz-F1 DNA binding domain interacts strongly with Ftz and dramatically facilitates the binding of Ftz to target DNA. PMID: 11520662

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR5 subfamily
  • 組織特異性：
    Expression in the parasegmental primordia of the embryonic blastoderm.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG4059

    STRING: 7227.FBpp0074853

    UniGene: Dm.995