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  4. Recombinant Drosophila melanogaster Suppressor of hairless protein (Su (H)), partial

Recombinant Drosophila melanogaster Suppressor of hairless protein (Su (H)), partial

  • 中文名稱：
    黑腹果蠅Su(H)重組蛋白
  • 貨號(hào)：
    CSB-YP328775DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Su(H)重組蛋白
  • 貨號(hào)：
    CSB-EP328775DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Su(H)重組蛋白
  • 貨號(hào)：
    CSB-EP328775DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Su(H)重組蛋白
  • 貨號(hào)：
    CSB-BP328775DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Su(H)重組蛋白
  • 貨號(hào)：
    CSB-MP328775DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Su(H)
  • Uniprot No.：
  • 別名：
    Su(H); dRBP-JK; CG3497; Suppressor of hairless protein; J kappa-recombination signal-binding protein; RBP-J kappa
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for neurogenesis in imaginal disks. In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development. Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell.
  • 基因功能參考文獻(xiàn)：
    1. complex genetic interactions of novel alleles deficient in co-repressor binding PMID: 29509808
    2. Structural models show that the Hairless-Su(H) repressor complexes from Daphnia and Drosophila are almost indistinguishable from one another. Amino acid residues in direct contact within the Hairless-Su(H) complex are at absolutely identical positions in the two homologues. PMID: 28861687
    3. Su(H) protein levels depend on the interactions with H as well as with Notch. PMID: 28475577
    4. X-ray structure of the Su(H)-Hairless complex bound to DNA. PMID: 27404588
    5. The role of Su(H) in conferring chromatin characteristics at Notch-regulated enhancers PMID: 26069324
    6. the molecular cross talk at the level of Suppressor of Hairless [Su(H)], is reported. PMID: 25452105
    7. human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly PMID: 25588307
    8. Su(H) repression acts as a counterbalance to Dorsal- and Zelda-mediated activation. PMID: 25313963
    9. This study demonistrated that transcriptional activity of Su(H) in Notch signaling in the mushroom bodies is critical for the formation of long-term memory. PMID: 19863271
    10. the C-terminal domain of Su(H) is necessary and sufficient for forming a high-affinity complex with Hairless PMID: 21737682
    11. Su(H)-H complexes can bind to DNA with high efficiency in vitro. Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. PMID: 12154126
    12. Loss of Su(H) function leads to an arrest of sensory organ precursors development PMID: 12642500
    13. the accumulation of Notch (N) in the late-endosome was required for the deltex -mediated Su(H)-independent N signaling PMID: 15496440
    14. crucial roles for the adaptor protein Hairless in conferring repressive activity on Su(H) in the Drosophila sensory organ precursor. PMID: 15975935
    15. acts on identified regulatoru seq pf roughest gene PMID: 16096801
    16. Su(H) acts as a transcriptional repressor in the absence of a Notch signal and as a transcriptional activator in its presence in several developmental contexts. PMID: 16397895

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Su(H) family
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG3497

    STRING: 7227.FBpp0080261

    UniGene: Dm.2288