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  4. Recombinant Human 17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14)

Recombinant Human 17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14)

  • 中文名稱：
    人HSD17B14重組蛋白
  • 貨號(hào)：
    CSB-YP859026HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HSD17B14重組蛋白
  • 貨號(hào)：
    CSB-EP859026HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HSD17B14重組蛋白
  • 貨號(hào)：
    CSB-BP859026HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HSD17B14重組蛋白
  • 貨號(hào)：
    CSB-MP859026HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HSD17B14
  • Uniprot No.：
  • 別名：
    HSD17B14; DHRS10; SDR3; SDR47C1; UNQ502/PRO47417-beta-hydroxysteroid dehydrogenase 14; 17-beta-HSD 14; EC 1.1.1.-; 17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-270
  • 氨基酸序列
    MATGTRYAGK VVVVTGGGRG IGAGIVRAFV NSGARVVICD KDESGGRALE QELPGAVFIL CDVTQEDDVK TLVSETIRRF GRLDCVVNNA GHHPPPQRPE ETSAQGFRQL LELNLLGTYT LTKLALPYLR KSQGNVINIS SLVGAIGQAQ AVPYVATKGA VTAMTKALAL DESPYGVRVN CISPGNIWTP LWEELAALMP DPRATIREGM LAQPLGRMGQ PAEVGAAAVF LASEANFCTG IELLVTGGAE LGYGCKASRS TPVDAPDIPS
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. Results show that tumoural expression levels of 17betaHSD14 can predict the outcome of adjuvant tamoxifen treatment in terms of local recurrence-free survival in patients with lymph node-negative ER+ breast cancer. PMID: 22792371
    2. crystal structure of the DHRS10 apoenzyme exhibits secondary structure of the SDR (short-chain dehydrogenase/reductase) family PMID: 17067289
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Highly expressed in brain, placenta, liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23238

    OMIM: 612832

    KEGG: hsa:51171

    STRING: 9606.ENSP00000263278

    UniGene: Hs.18788