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  4. Recombinant Human 26S proteasome non-ATPase regulatory subunit 2 (PSMD2), partial

Recombinant Human 26S proteasome non-ATPase regulatory subunit 2 (PSMD2), partial

  • 中文名稱：
    人PSMD2重組蛋白
  • 貨號：
    CSB-YP619755HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PSMD2重組蛋白
  • 貨號：
    CSB-EP619755HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PSMD2重組蛋白
  • 貨號：
    CSB-EP619755HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PSMD2重組蛋白
  • 貨號：
    CSB-BP619755HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PSMD2重組蛋白
  • 貨號：
    CSB-MP619755HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PSMD2
  • Uniprot No.：
  • 別名：
    26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; MGC14274; P97; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit; non-ATPase; 2; Proteasome 26S; subunit 2; Protein 55.11; Psmd2; PSMD2_HUMAN; Rpn1; S2; TNFR associated protein 2; TRAP2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.; Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
  • 基因功能參考文獻：
    1. the high-resolution solution structure of the UBL domain of human UBLCP1 and its interaction with Rpn1 PMID: 23667555
    2. Results suggest that PSMD2 may be a good molecular target candidate. PMID: 21465578
    3. These data suggest that p97 recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes. PMID: 19815544
    4. U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome inhibition. PMID: 18337449
    5. Data show that data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation. PMID: 19638347
    6. the 26S proteasome may provide a general predictive biomarker for radiotherapy outcome. PMID: 19881955

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  • 蛋白家族：
    Proteasome subunit S2 family
  • 組織特異性：
    Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9559

    OMIM: 606223

    KEGG: hsa:5708

    STRING: 9606.ENSP00000310129

    UniGene: Hs.518464