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  4. Recombinant Human Beta-1,4-galactosyltransferase 7 (B4GALT7), partial

Recombinant Human Beta-1,4-galactosyltransferase 7 (B4GALT7), partial

  • 中文名稱：
    Recombinant Human Beta-1,4-galactosyltransferase 7(B4GALT7),partial
  • 貨號：
    CSB-YP890666HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Beta-1,4-galactosyltransferase 7(B4GALT7),partial
  • 貨號：
    CSB-EP890666HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Beta-1,4-galactosyltransferase 7(B4GALT7),partial
  • 貨號：
    CSB-EP890666HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Beta-1,4-galactosyltransferase 7(B4GALT7),partial
  • 貨號：
    CSB-BP890666HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Beta-1,4-galactosyltransferase 7(B4GALT7),partial
  • 貨號：
    CSB-MP890666HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    B4GALT7
  • Uniprot No.：
  • 別名：
    B4GALT7; XGALT1; UNQ748/PRO1478Beta-1,4-galactosyltransferase 7; Beta-1,4-GalTase 7; Beta4Gal-T7; b4Gal-T7; EC 2.4.1.-; Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; XGPT; XGalT-1; Xylosylprotein 4-beta-galactosyltransferase; EC 2.4.1.133; Xylosylprotein beta-1,4-galactosyltransferase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點(diǎn)詳情

  • 功能：
    Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
  • 基因功能參考文獻(xiàn)：
    1. The phenotypes described in this article caused by bi-allelic mutations in B4GALT7 would benefit from reclassification and loss of its current association with PEDS. These conditions would be better grouped with the other linkeropathies. PMID: 26940150
    2. Our findings demonstrate that B4GALT7 is the causative gene for LRS. The identification of a unique homozygous mutation argues in favor of a founder effect. B4GALT7 encodes a galactosyltransferase. PMID: 24755949
    3. identified two key structural features forming stacking interactions with the aglycone, and the hydrogen bond between the His(195) nitrogen backbone and the carbonyl group of the coumarinyl molecule to develop a tight binder of hbeta4GalT7 PMID: 25568325
    4. a Michaelis complex of a glycosyltransferase has been described, and it clearly suggests an SN2 type catalytic mechanism for the beta4GalT7 enzyme. PMID: 24052259
    5. Two evolutionary conserved motifs, (163)DVD(165) and (221)FWGWGREDDE(230), are central in the organization of the enzyme active site. PMID: 20843813
    6. Mutated ennzyme affects glycosaminoglycan synthesis and is involved Ehlers-Danlos syndrome. PMID: 20809901
    7. This study establishes the molecular basis for beta4GalT7 defects associated with altered GAG synthesis in Ehlers-Danlos syndrome. PMID: 20691685
    8. phosphorylation of Xyl on the C-2 position prevents GalT-I activity PMID: 15522873
    9. reduced beta4GalT-7 activity resulting in defective glycosylation of decorin and biglycan may be responsible for the complex molecular pathology in beta4GalT-7 deficient Ehlers-Danlos syndrome patients PMID: 16583246
    10. Study suggests an heparan sulfate-dependent basic mechanism behind the altered wound repair phenotype of beta4GalT-7-deficient Ehlers-Danlos syndrome patients. PMID: 18158310

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  • 相關(guān)疾?。?/div>
    Ehlers-Danlos syndrome with short stature and limb anomalies (EDSSLA)
  • 亞細(xì)胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Cis cisternae of Golgi stack.
  • 蛋白家族：
    Glycosyltransferase 7 family
  • 組織特異性：
    High expression in heart, pancreas and liver, medium in placenta and kidney, low in brain, skeletal muscle and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 930

    OMIM: 130070

    KEGG: hsa:11285

    STRING: 9606.ENSP00000029410

    UniGene: Hs.455109