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  4. Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

  • 中文名稱：
    Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)
  • 貨號：
    CSB-EP750768HU
  • 規(guī)格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    JMJD6
  • Uniprot No.：
  • 別名：
    Histone arginine demethylase JMJD6;JmjC domain-containing protein 6;Jumonji domain-containing protein 6;Lysyl-hydroxylase JMJD6;Peptide-lysine 5-dioxygenase JMJD6;Phosphatidylserine receptor;Protein PTDSR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    53.4 kDa
  • 表達區(qū)域：
    1-403aa
  • 氨基酸序列
    MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
  • 基因功能參考文獻：
    1. JMJD6 regulates VHL gene expression in the human placenta. VHL downregulation in preeclampsia is dependent on decreased JMJD6 demethylase activity due to hypoxia and reduced Fe2+ bioavailability. PMID: 29373688
    2. In tumor samples but not normal breast tissue, the expression of JMJD6 linearly correlated with HOTAIR suggesting that JMJD6-mediated up-regulation may occur specifically in tumors. PMID: 29229759
    3. Results show that JMJD6 is up-regulated in melanoma, and high expression of JMJD6 protein is strongly correlated with advanced stages and aggressiveness of melanoma. It enhances the MAPK signaling through regulation of alternative splicing of PAK1 promoting multiple cellular processes including melanogenesis, proliferation, invasion, and angiogenesis in melanoma cells. PMID: 29187213
    4. High JMJD6 expression is associated with Neuroblastomas. PMID: 28684529
    5. miR-770 acted on a tumor suppressor by binding to the 3'UTR of JMJD6 and downregulated its expression in NSCLC cells; this study also demonstrated that JMJD6 played as an oncogene in NSCLC cells PMID: 28882645
    6. AcK27-HOXB9 suppresses the transcription of its target gene Jumonji domain-containing protein 6 (JMJD6) by direct occupying the promoter of JMJD6 gene. PMID: 27613418
    7. These findings provide evidence that JMJD6 may play a role in regulating the production of sFLT-1 in the preeclamptic placenta. Decreased placental JMJD6 expression may be an important component to the pathophysiology of preeclampsia. PMID: 26819475
    8. Study identified a novel epigenetic mechanism showing how JMJD6 cooperates with Myc during oncogenic transformation. Combined high expression of Myc and JMJD6 confers a more aggressive phenotype in mouse and human tumors. PMID: 27081402
    9. Our studies identify JMJD6 as a molecular determinant of cancer stem cell phenotype PMID: 26645717
    10. Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer PMID: 25951181
    11. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B. PMID: 25219359
    12. A novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia. PMID: 26037477
    13. JMJD6 is a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention. PMID: 24667498
    14. Study reports that a unique cohort of JMJD6 and Brd4 cobound distal enhancers, termed anti-pause enhancers, regulate promoter-proximal pause release of a large subset of transcription units via long-range interactions. PMID: 24360279
    15. The structure of Jmjd6 oligomers in vitro changes in the absence of the polyS domain, possibly reflecting the role of the polyS domain in nuclear/nucleolar shuttling of Jmjd6. PMID: 23688307
    16. results showed that JMJD6 plays a key role in lung adenocarcinoma and therefore may provide an opportunity for developing a novel therapeutic target as well as a prognostic marker in lung adenocarcinoma. PMID: 23595221
    17. histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase PMID: 23303181
    18. data indicate JMJD6 has conserved functions and often affects similar pathways across multiple cell types; it has ability to promote cancer cell proliferation and motility; JMJD6 is a novel biomarker of tumor aggressiveness with functional implications in breast cancer growth and migration PMID: 22621393
    19. Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis. PMID: 22701020
    20. we did not detect arginine demethylase activity for Jmjd6, but we did confirm that it could catalyze the lysyl-hydroxylation of histone peptides PMID: 22189873
    21. Jmjd6 regulates the splicing of Flt1, thereby controlling angiogenic sprouting. PMID: 21300889
    22. Data show that JMJD6 bound efficiently to single-stranded RNA, but not to single-stranded DNA, double-stranded RNA, or double-stranded DNA. PMID: 20679243
    23. crystallographic studies on the catalytic domain of JMJD6 in complex with Ni(II) substituting for Fe(II) PMID: 20684070
    24. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. PMID: 11877474
    25. plays a major role in the clearance of apoptotic cells from the thymus. PMID: 15072554
    26. Homomultimer of PS-R might be playing an important function as a scaffolding protein in the nucleus. PMID: 17534701
    27. study demonstrates that JMJD6 is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays PMID: 17947579
    28. Jmjd6 is predicted to have a conserved enzymatic function as a classical non-heme, Fe(II)- and 2OG-dependent dioxygenase, and is closely related to the JmjC domain-containing proteins Jmjd4 and JFP6. PMID: 18564434
    29. Jmjd6 serves as a membrane-associated receptor that regulates phagocytosis in immature macrophages but is dispensable for phagocytosis. PMID: 19492415
    30. study reveals the splicing factor U2AF65 undergoes posttranslational lysyl-5-hydroxylation catalyzed by Jmjd6; Jmjd6 is shown to change alternative RNA splicing of some endogenous & reporter genes, supporting a role for Jmjd6 in regulation of RNA splicing PMID: 19574390
    31. The mouse ortholog of Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance. PMID: 15345036

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  • 亞細胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    JMJD6 family
  • 組織特異性：
    Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nurs
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19355

    OMIM: 604914

    KEGG: hsa:23210

    STRING: 9606.ENSP00000394085

    UniGene: Hs.514505