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  4. Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1), partial

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1), partial

  • 中文名稱：
    Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1(CELSR1) ,partial
  • 貨號：
    CSB-YP868360HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1(CELSR1) ,partial
  • 貨號：
    CSB-EP868360HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1(CELSR1) ,partial
  • 貨號：
    CSB-EP868360HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1(CELSR1) ,partial
  • 貨號：
    CSB-BP868360HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 1(CELSR1) ,partial
  • 貨號：
    CSB-MP868360HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CELSR1; CDHF9; FMI2Cadherin EGF LAG seven-pass G-type receptor 1; Cadherin family member 9; Flamingo homolog 2; hFmi2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor that may have an important role in cell/cell signaling during nervous system formation.
  • 基因功能參考文獻(xiàn)：
    1. Patients with CELSR1 mutations and spina bifida can have significant renal malformations. PMID: 27597235
    2. This single-nucleotide polymorphism-by-sex genome-wide association analysis identified the fetal lung development gene, CELSR1, as a potential sex-specific risk factor for Chronic obstructive pulmonary disease. PMID: 27854507
    3. Upregulating CELSR1 expression significantly promoted cell growth, while knocking down CELSR1 inhibited the growth and decreased tube formation. PMID: 27301287
    4. Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients. PMID: 25855559
    5. the present study has proven for the first time that CELSR1 is a susceptibility gene for ischaemic stroke in the Chinese Han population, especially for large artery atherosclerosis. PMID: 25117632
    6. CELSR1 mutations contribute to the risk of spina bifida in a cohort of spina bifida patients from California PMID: 24632739
    7. Celsr1 regulates dynamic cell movements by inhibiting stabilization of VE-cadherin and maturation of adherens junctions. PMID: 23792146
    8. CELSR1 is a risk factor for neural tube defects or caudal agenesis via pathogenic role of planar cell polarity signaling in these malformations. PMID: 22371354
    9. Missense variants in CELSR1 may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism. PMID: 22095531
    10. CELSR1 may have a role in ischemic stroke, as shown in a Portuguese case-control cohort PMID: 21511255
    11. The planar cell polarity genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. PMID: 20223754
    12. Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. PMID: 19403135
    13. exclusion as a candidate gene for schizophrenia-- a cadhrin gene PMID: 11807409
    14. Variations in the nine ectodomains of CELSR1 do not increase susceptibility to schizophrenia. PMID: 12782967

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  • 相關(guān)疾?。?/div>
    Neural tube defects (NTD)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1850

    OMIM: 182940

    KEGG: hsa:9620

    STRING: 9606.ENSP00000262738

    UniGene: Hs.252387