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  4. Recombinant Human Condensin complex subunit 3 (NCAPG), partial

Recombinant Human Condensin complex subunit 3 (NCAPG), partial

  • 中文名稱：
    人NCAPG重組蛋白
  • 貨號：
    CSB-YP857766HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NCAPG重組蛋白
  • 貨號：
    CSB-EP857766HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NCAPG重組蛋白
  • 貨號：
    CSB-EP857766HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NCAPG重組蛋白
  • 貨號：
    CSB-BP857766HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NCAPG重組蛋白
  • 貨號：
    CSB-MP857766HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NCAPG
  • Uniprot No.：
  • 別名：
    CAPG; CHCG; Chromosome associated protein G; Chromosome condensation protein G; Chromosome-associated protein G; CND3_HUMAN; Condensin complex subunit 3; Condensin subunit CAP G; Condensin subunit CAP-G; HCAP G; hCAP-G; Melanoma antigen NY MEL 3; Melanoma antigen NY-MEL-3; NCAPG; Non SMC condensin I complex subunit G; Non-SMC condensin I complex subunit G; NY MEL 3; XCAP G homolog; XCAP-G homolog
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

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靶點詳情

  • 功能：
    Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 基因功能參考文獻：
    1. this study demonstrates that NCAPG plays an important role in the development and progression of hepatocellular carcinoma (HCC), and that it may be a novel therapeutic target for patients with HCC. PMID: 28737823
    2. Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets. PMID: 26933822
    3. Mutation of threonines 308 and 322 to alanines results in defects in CAP-G localization with chromosomes during mitosis. PMID: 18977199
  • 亞細胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    CND3 (condensin subunit 3) family
  • 組織特異性：
    Highly expressed in testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24304

    OMIM: 606280

    KEGG: hsa:64151

    STRING: 9606.ENSP00000251496

    UniGene: Hs.567567