搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Dual oxidase 1 (DUOX1), partial

Recombinant Human Dual oxidase 1 (DUOX1), partial

  • 中文名稱：
    人DUOX1重組蛋白
  • 貨號：
    CSB-YP007228HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DUOX1重組蛋白
  • 貨號：
    CSB-EP007228HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DUOX1重組蛋白
  • 貨號：
    CSB-EP007228HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DUOX1重組蛋白
  • 貨號：
    CSB-BP007228HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DUOX1重組蛋白
  • 貨號：
    CSB-MP007228HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DUOX1
  • Uniprot No.：
  • 別名：
    DUOX1; DUOX; LNOX1; THOX1Dual oxidase 1; EC 1.11.1.-; EC 1.6.3.1; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; Thyroid oxidase 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關產(chǎn)品

靶點詳情

  • 功能：
    Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
  • 基因功能參考文獻：
    1. Authors demonstrate here that DUOX1 is silenced in breast cancer, which seems to be involved in breast carcinogenesis. PMID: 29849884
    2. Silencing DUOX1 by siRNA attenuated IL-13-mediated increases in superoxide, but did not reduce autophagy activities. PMID: 28982074
    3. We analyzed the expression of NADPH oxidase isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1).Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1. PMID: 27262981
    4. DUOX1 missense mutation plays a role in congenital hypothyroidism. PMID: 28633507
    5. Our findings implicate epithelial DUOX1 as a pivotal mediator of IL-33-dependent activation of innate airway type 2 immune responses to common airborne allergens and indicate that enhanced DUOX1 expression and IL-33 secretion might present important contributing features of allergic asthma. PMID: 26597162
    6. Cox multivariate regression analysis demonstrated that DUOX1, GLS2, FBP1 and age were independent risk factors for the prognosis of HCC patients after surgery PMID: 27079415
    7. DUOX1 expression in liver tumors is a potential prognostic tool for patients. PMID: 27108801
    8. Nox4 and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF. PMID: 27110716
    9. These data reveal a key role of DUOX1-dependent hydrogen peroxide production in long-term persistent radio-induced DNA damage. PMID: 25848056
    10. Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK signaling pathways involved in cell migration. PMID: 24624333
    11. Duox2 proteins possessing the A-loops of Nox1 or Nox5 co-expressed with DuoxA2 showed enhanced O2 () release, and Duox1 proteins possessing the A-loops of Nox1 or Nox5 co-expressed with DuoxA1 acquired O2 () leakage PMID: 25586178
    12. DUOX1 is the major H2O2-producing source in NHKs stimulated with Ca(2+), and plays a significant role in regulating the expression of specific markers necessary for the normal differentiation of keratinocytes PMID: 24332816
    13. Further, ROS generated by Duox enzymes localized adjacent to nuclear speckles altered the splicing of viral genes PMID: 24128054
    14. Despite the high sequence similarity shared between DUOX1 and DUOX2, the two isoforms present distinct regulations, tissue expression and catalytic functions PMID: 24161126
    15. Duox1 activity is stimulated by testosterone through GPRC6A in skin keratinocytes PMID: 25164816
    16. Underscore the importance of DUOX1 and DUOX2 in vesicant-induced IL-6 secretion in human airway epithelial cells. PMID: 24164541
    17. upregulated in chronic rhinosinusitis as a part of inflammatory response PMID: 23281318
    18. PA-LPS-induced MUC5AC and Clca3 expression is partly through Duox1 PMID: 23691121
    19. DUOX1 plays a central role in epithelial defense responses to infection or injury, by mediating oxidative activation of Src and ADAM17 in response to ATP-dependent P2Y(2)R activation as a proximal step in EGFR transactivation and downstream signaling. PMID: 23349873
    20. Report shows that ROS levels in PC3 cells are constitutively maintained by DUOX 1 and 2 enzymes, and these ROS positively regulate AKT signalling through inactivating phosphatases, leading to increased resistance to apoptosis. PMID: 23225414
    21. Study indicates a complex profile of protein interactions required for activity and localization of the DUOX1 and DOOX2 enzymes. PMID: 23362256
    22. study reports DUOX 1 and 2 are expressed in neuroblastoma SK-N-BE cells as well as in an oligodendrocyte cell line (MO3-13); data unravel a novel mechanism of regulation of DUOX enzymes by reactive oxygen species and identify a circuitry linking NADPH oxidase activity to DUOX1 and 2 levels in neuroblastoma cells PMID: 22523549
    23. Data show that comparing with adjacent non-neoplastic tissues, DUOX1, DUOX2, and NOX4 were expressed at higher frequencies in tumor specimens. PMID: 21915726
    24. results demonstrate Duox1-mediated redox signaling in bronchial epithelial cells is associated with Lipid raft clustering dependent on the production of ceramide through acid sphingomyelinase PMID: 21389273
    25. Data demonstrated that the increased expression of DUOX1 in IL-4/IL-13-treated NHEK augments STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B. PMID: 21411736
    26. activation of Duox1, downstream of proximal TCR signals, generates H(2)O(2) that acts in a positive feedback loop to enhance and sustain further TCR signaling. PMID: 20682913
    27. Results found that Pseudomonas aeruginosa triggers H2O2 production by Duox1 in bronchial epithelial cells in a calcium-dependent but predominantly ATP-independent manner. PMID: 20085766
    28. TPO binds to dualoxidases;defects in this association could impair thyroid hormone synthesis and lead to thyroid insufficiency and cell damage. PMID: 19952225
    29. Thox1 is expressed in aortic media and either not at all or rarely in unaffected intima, while mRNA expression in cells is greatest in fibrofatty lesions. PMID: 12482831
    30. chromosomal organization of hThOX1 and hThOX2 genes and the functional characterization of their respective promoter regions PMID: 15062544
    31. EFP1 is a thioredoxin-related protein and partner of duox PMID: 15561711
    32. Duox1 plays a critical role in mucin expression by airway epithelial cells through PKCdelta/PKC-Duox1-ROS-TACE-pro-ligand-EGF receptor cascade. PMID: 15640347
    33. These data suggest that Duox1 and 2 are the major NADPH oxidases expressed in airway epithelia and therefore contributors of hydrogen peroxide production in the airway lumen. PMID: 15677770
    34. Results demonstrate the regulation of Duox1 and 2 expression by Th1 and Th2 cytokines, and suggest a mechanism by which ROS production can be regulated in the respiratory tract as part of the host defense response. PMID: 16111680
    35. In conclusion, incubation of normal or GD thyrocytes with Th1 cytokines induces a significant reduction in TSH-increased expression of both TPO and ThOXs, an effect partially mediated by NO. PMID: 16478776
    36. Critical role for dual oxidase 1 within the tracheobronchial epithelium, in airway epithelial cell migration and repair following injury. PMID: 17135261
    37. there is regulated expression of DUOX1 during alveolar maturation, and DUOX1 mediates alveolar H(2)O(2) and acid secretion by differentiated type II cells PMID: 17337509
    38. Results imply that the airway expression of Duox1 is diversely associated with smoking and chronic obstructive pulmonary disease. PMID: 18177232
    39. Results suggest that an area on chromosome 15 that includes DUOX1, DUOX2, and their maturation factors is a frequent target for epigenetic silencing in lung cancer. PMID: 18281478
    40. a novel, inhibitory function for Noxa1 in Duox1 regulation. PMID: 18606821
    41. Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. PMID: 19144650
    42. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. PMID: 19339556
    43. analysis of heme binding and catalytic activity of Caenorhabditis elegans and human dual oxidase 1 PMID: 19460756

    顯示更多

    收起更多

  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.
  • 蛋白家族：
    Peroxidase family
  • 組織特異性：
    Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3062

    OMIM: 606758

    KEGG: hsa:53905

    STRING: 9606.ENSP00000317997

    UniGene: Hs.272813