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  4. Recombinant Human Histone-lysine N-methyltransferase SETD1A (SETD1A), partial

Recombinant Human Histone-lysine N-methyltransferase SETD1A (SETD1A), partial

  • 中文名稱：
    人SETD1A重組蛋白
  • 貨號：
    CSB-YP021101HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SETD1A重組蛋白
  • 貨號：
    CSB-EP021101HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SETD1A重組蛋白
  • 貨號：
    CSB-EP021101HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SETD1A重組蛋白
  • 貨號：
    CSB-BP021101HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SETD1A重組蛋白
  • 貨號：
    CSB-MP021101HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SETD1A
  • Uniprot No.：
  • 別名：
    Histone-lysine N-methyltransferase SETD1A; hSET1A; KMT2F; Lysine N methyltransferase 2F; Lysine N-methyltransferase 2F; SET domain containing 1A; SET domain containing protein 1A; SET domain-containing protein 1A; SET1; Set1 Ash2 histone methyltransferase complex subunit SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SET1A_HUMAN; SETD1A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated.
  • 基因功能參考文獻：
    1. SETD1A contributes to retinoic acid -induced thrombomodulin expression in vascular endothelial cells by modulating the activity and expression of KLF4. PMID: 29940355
    2. Study showed that repressed HBV cccDNA chromatin state is activated by Set1A which mediates its activation by methylating H3K4. Also, Set1A was showed to be recruited to viral promoters in an HBx dependent manner. PMID: 27174370
    3. Rare loss-of-function variants in SETD1A are associated with Schizophrenia and Developmental disorders. SETD1A is the only gene implicated to date by whole-exome sequencing studies. PMID: 28969442
    4. data indicate that Setd1a and NURF complexes are specifically targeted to and coordinately regulate erythroid promoter chromatin dynamics during erythroid lineage differentiation PMID: 27141965
    5. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. PMID: 27563068
    6. Study provides evidence that increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates CREMA in systemic lupus erythematosus. PMID: 27904655
    7. the expression of hSETD1A occurs at a high rate in hepatocellular carcinoma patients. The expression state of hSETD1A may be a prognostic factor in hepatocellular carcinoma. PMID: 27656834
    8. Collectively called the WRAD complex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression. PMID: 28229975
    9. Given the critical tumor suppressor role of p53, SETD1A-mediated suppression of this pathway (even in the absence of p53 mutations), would be predicted to have profound consequences on tumorigenesis. PMID: 26865005
    10. Findings provide evidence that SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically. PMID: 26581161
    11. Loss-of-function variants in SETD1A cause a range of neurodevelopmental disorders in a Finnish population. PMID: 26974950
    12. Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors PMID: 26691508
    13. This study demonstrated that SETD1A mutation showing the highest statistical significance in Autism and Schizophrenia. PMID: 26938441
    14. suppresses BTG2 expression through its induction of several BTG2-targeting miRNAs PMID: 26394836
    15. Set1/MLL complex is indispensable for the transcriptional ability of HSF2. PMID: 26478434
    16. Study reveals that SETD1A controls tumor metastasis by activating matrix metalloproteinases (MMP) expression and provides an epigenetic link among SETD1A, MMPs, and metastasis of breast cancer. PMID: 25373480
    17. Co-immunoprecipitation demonstrated LANA association with endogenous hSET1 complexes in both lymphoid and endothelial cells suggesting that LANA may contribute to the epigenetic profile of KSHV episomes PMID: 25033463
    18. Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS PMID: 25542209
    19. these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo. PMID: 25561738
    20. This study demonistrated that Loss-of-function variants of loss of function variants of SETD1A is a canadate susceptibility of Schizophrenia. PMID: 24853937
    21. hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells. PMID: 24247718
    22. These results demonstrate that the increase of H3K4me3 by human Set1 complex is involved in activation of lytic genes during the lytic infection of KSHV. PMID: 23306522
    23. A synergistic role of hSET1 and NURF in regulating the USF-bound barrier insulator to prevent erythroid genes from encroachment of heterochromatin. PMID: 21653943
    24. HCF-1 was required for recruitment of the histone methyltransferases Set1 and MLL1, leading to histone H3K4 trimethylation and transcriptional activation. PMID: 17578910
    25. suggest a model for how the mammalian RNA polymerase II machinery is linked with histone H3-Lys4 histone methyltransferase complexes at transcriptionally active genes PMID: 17998332
    26. Data show that Wdr82, which associates with chromatin in a histone H2B ubiquitination-dependent manner, is a specific component of Set1 complexes but not that of MLL1-4 complexes. PMID: 18838538

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  • 亞細胞定位：
    Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29010

    OMIM: 611052

    KEGG: hsa:9739

    STRING: 9606.ENSP00000262519

    UniGene: Hs.297483