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  4. Recombinant Human Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)

Recombinant Human Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)

  • 中文名稱：
    人ISCA1重組蛋白
  • 貨號：
    CSB-YP887126HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ISCA1重組蛋白
  • 貨號：
    CSB-EP887126HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ISCA1重組蛋白
  • 貨號：
    CSB-EP887126HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ISCA1重組蛋白
  • 貨號：
    CSB-BP887126HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ISCA1重組蛋白
  • 貨號：
    CSB-MP887126HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ISCA1
  • Uniprot No.：
  • 別名：
    GK004; HESB-like domain-containing protein 2; hIscA; Iron sulfur assembly protein IscA; Iron-sulfur assembly protein IscA; Iron-sulfur cluster assembly 1 homolog; Iron-sulfur cluster assembly 1 homolog, mitochondrial; ISCA1; ISCA1_HUMAN; mitochondrial
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    13-129
  • 氨基酸序列
    VSKRKLQP TRAALTLTPS AVNKIKQLLK DKPEHVGVKV GVRTRGCNGL SYTLEYTKTK GDSDEEVIQD GVRVFIEKKA QLTLLGTEMD YVEDKLSSEF VFNNPNIKGT CGCGESFNI
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
  • 基因功能參考文獻(xiàn)：
    1. the phenotype observed in all affected subjects with the ISCA1 pathogenic variant is similar to that previously described in all four types of multiple mitochondrial dysfunctions syndromes. PMID: 28356563
    2. The structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 is the crucial factor that allows an efficient cluster transfer to the partner proteins human ISCA1 and ISCA2 by a specific protein-protein recognition mechanism. PMID: 24733926
    3. The data presented here show that the Isu1 suppressor mimics the frataxin effects on Nfs1, explaining the bypassing activity. PMID: 24217246
    4. ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. PMID: 22323289
    5. Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1 PMID: 20302570
    6. screening a human brain cDNA expression library with serum from a patient suffering from the autoimmune Sjogren's syndrome yielded a gene product called hIscA implicated in iron-sulfur cluster biogenesis PMID: 15262227
    7. Required for functional heme biosynthesis in erythroid cells. PMID: 19656490

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  • 相關(guān)疾病：
    Multiple mitochondrial dysfunctions syndrome 5 (MMDS5)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    HesB/IscA family
  • 組織特異性：
    Detected in cerebellum, kidney and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28660

    OMIM: 611006

    KEGG: hsa:81689

    STRING: 9606.ENSP00000365159

    UniGene: Hs.449291