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  4. Recombinant Human Microtubule-associated protein 4 (MAP4), partial

Recombinant Human Microtubule-associated protein 4 (MAP4), partial

  • 中文名稱：
    人MAP4重組蛋白
  • 貨號：
    CSB-YP013435HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAP4重組蛋白
  • 貨號：
    CSB-EP013435HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAP4重組蛋白
  • 貨號：
    CSB-EP013435HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAP4重組蛋白
  • 貨號：
    CSB-BP013435HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAP4重組蛋白
  • 貨號：
    CSB-MP013435HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MAP4
  • Uniprot No.：
  • 別名：
    DKFZp779A1753; MAP-4; MAP4; MAP4_HUMAN; MGC8617; Microtubule associated protein 4; Microtubule-associated protein 4; OTTHUMP00000210723; OTTHUMP00000210725; OTTHUMP00000210727; OTTHUMP00000210730
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
  • 基因功能參考文獻：
    1. Expression level of MAP4 mRNA and protein in lung adenocarcinoma tissues were significantly higher than those in noncancerous tissues. MAP4 expression significantly correlated with tumor progression. PMID: 29743960
    2. Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. PMID: 27911820
    3. an intratumoral injection of MAP4-small interfering RNA (siRNA) remarkably inhibited the growth of the tumors that formed by the MAP4-expressing ESCC cells in nude mice, and a combination of MAP4-siRNA and Bevacizumab significantly enhanced the inhibition effect. Our data suggest that MAP4 is probably a useful prognostic biomarker and a potential therapeutic target for the disease. PMID: 26876215
    4. MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation. PMID: 28209780
    5. Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure. PMID: 26866982
    6. We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK pathway activation by the LPS and TNF-alpha stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability. PMID: 25746230
    7. Results demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature. PMID: 25323976
    8. Data show that cAMP/alpha isoform of the catalytic subunit of human PKA (PKAc-alpha) signaling can disrupt microtubule (MT) cytoskeleton by the phosphorylation of microtubule-Associated Protein 4 (MAP4). PMID: 24140250
    9. MAP4, which is a binding partner of SEPT2. PMID: 23572511
    10. there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization PMID: 22164227
    11. DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation. PMID: 22018492
    12. Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis. PMID: 21822276
    13. Results suggest that structural features of the PJ domain of MAP4 may contribute to the formation of a radial array of microtubules in proliferating cells. PMID: 12079337
    14. demonstrate that ectopic MAP4 promotes outgrowth of extended MTs during beta1-integrin-induced cell spreading PMID: 12123579
    15. activity of MAP4 is downregulated by reduced free tubulin concentrations PMID: 12890753
    16. adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters PMID: 14527689
    17. MAP4 microtubule decoration interferes with beta-adrenergic receptor recycling and that this may be one mechanism for beta-adrenergic receptor downregulation in heart failure. PMID: 15528234
    18. Truncation of the projection domain of MAP4 leads to attenuation of microtubule dynamic instability. PMID: 15840946
    19. mAP4 interaction with septins modulates microtubule dynamics. PMID: 16093351
    20. This first report of a genetic alteration involving MAP4 points to a potentially relevant target gene in diffuse large B-cell lymphoma. PMID: 16804917

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6862

    OMIM: 157132

    KEGG: hsa:4134

    STRING: 9606.ENSP00000353375

    UniGene: Hs.517949