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  4. Recombinant Human MutS protein homolog 4 (MSH4), partial

Recombinant Human MutS protein homolog 4 (MSH4), partial

  • 中文名稱：
    人MSH4重組蛋白
  • 貨號：
    CSB-YP015030HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MSH4重組蛋白
  • 貨號：
    CSB-EP015030HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MSH4重組蛋白
  • 貨號：
    CSB-EP015030HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MSH4重組蛋白
  • 貨號：
    CSB-BP015030HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MSH4重組蛋白
  • 貨號：
    CSB-MP015030HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MSH4
  • Uniprot No.：
  • 別名：
    hMSH4; MSH 4; MSH4; MSH4_HUMAN; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
  • 基因功能參考文獻：
    1. Study describes the first MSH4 mutation associated with POI and increases the number of meiotic/DNA repair genes formally implicated as being responsible for this condition. PMID: 28541421
    2. inactivation of MSH4 in germ cells may have played a role in the acquisition of additional TP53 and LATS1 germline mutations in a Li-Fraumeni family PMID: 25041856
    3. hMSH4 interacts with HDAC3. PMID: 24145748
    4. Our current study has revealed a role for hMSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair. PMID: 23725059
    5. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages PMID: 21126912
    6. The different properties associated with these two hMSH5 variants underscore the potential functional diversity of the human hMSH5 gene. PMID: 15907804
    7. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination. PMID: 16122992
    8. A review of the properties and functional roles of MSH4. PMID: 17127347
    9. Dimerization of MSH4 and MSH5 facilitates their nuclear localization suggesting that dimerization may regulate the intracellular trafficking of these proteins. PMID: 17869244
    10. Data have identified the interaction region between the individual subunits of hMSH4-hMSH5 that are likely involved in clamp formation and show that each subunit of the heterodimer binds ATP. PMID: 17977839
    11. Data show that there is no association between MSH4 gene mutation and premature ovarian failure. PMID: 18166824

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  • 亞細胞定位：
    Chromosome.
  • 蛋白家族：
    DNA mismatch repair MutS family
  • 組織特異性：
    Testis and ovary specific.
  • 數據庫鏈接：

    HGNC: 7327

    OMIM: 602105

    KEGG: hsa:4438

    STRING: 9606.ENSP00000263187

    UniGene: Hs.216639