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  4. Recombinant Human Pleckstrin homology domain-containing family F member 2 (PLEKHF2)

Recombinant Human Pleckstrin homology domain-containing family F member 2 (PLEKHF2)

  • 中文名稱：
    人PLEKHF2重組蛋白
  • 貨號：
    CSB-EP884492HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    110070J07Rik; AA673237; FLJ13187; PH and FYVE domain containing protein 2; PH and FYVE domain-containing protein 2; PH domain containing family F member 2; PH domain-containing family F member 2; Phafin 2; Phafin-2; PHAFIN2; PKHF2_HUMAN; pleckstrin homology domain containing, family F (with FYVE domain) member 2; pleckstrin homology domain containing, family F (with FYVE domain) member2 ; Pleckstrin homology domain-containing family F member 2; Plekhf2; ZFYVE18; Zinc finger FYVE domain containing protein 18 ; Zinc finger FYVE domain-containing protein 18
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    54.8kDa
  • 表達區(qū)域：
    1-249aa
  • 氨基酸序列
    MVDRLANSEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGDMATCQPARSDSYSQSLKSPLNDMSDDDDDDDSSD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal GST-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
  • 基因功能參考文獻：
    1. PtdIns(3)P binding to Phafin2 occurs with high affinity, triggering minor conformational changes in the protein. Taken together, these studies represent a platform for establishing the structural basis of Phafin2 molecular interactions and the role of the two potentially redundant PtdIns(3)P-binding domains of the protein in endomembrane compartments. PMID: 28152563
    2. These findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with phosphatidylinositol 3 phosphate. PMID: 24416124
    3. Phafin2 controls EGFR trafficking through early endosomes by facilitating endosome fusion in concert with EEA1. PMID: 22816767
    4. These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. PMID: 19995552
    5. Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway. PMID: 18288467

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  • 亞細胞定位：
    Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum.
  • 組織特異性：
    Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20757

    OMIM: 615208

    KEGG: hsa:79666

    STRING: 9606.ENSP00000322373

    UniGene: Hs.29724