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  4. Recombinant Human Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

Recombinant Human Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

  • 中文名稱：
    Recombinant Human Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)
  • 貨號：
    CSB-MP018200HU
  • 規(guī)格：
    ￥1908
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    Lysyl hydroxylase 2;LH2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    Mammalian cell
  • 分子量：
    83.4 kDa
  • 表達區(qū)域：
    26-737aa
  • 氨基酸序列
    ADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
  • 基因功能參考文獻：
    1. Findings suggest that Acanthamoeba polyphaga mimivirus L230 co-evolved with human collagen lysyl hydroxylases (LHs). PMID: 29410444
    2. Gain- and loss-of-function studies and orthotopic implantation metastasis model pinpointed that PLOD2 promotes NSCLC metastasis directly by enhancing migration and indirectly by inducing collagen reorganization. PMID: 29072684
    3. knockdown of endogenous PLOD2 suppresses glioma cell proliferation, migration and invasion through modulating multiple EMT-associated factors via inactivation of PI3K/AKT signaling. PMID: 28410212
    4. Only the mechanisms of PLOD2 regulated by HIF-1alpha, TGF-beta and microRNA-26a/b have been elaborated. PMID: 28415047
    5. Hypoxia upregulated PLOD2 protein in U87 and U251 human glioma cell lines. PMID: 28423580
    6. This study reports for the first time the expression of PLOD2 in Brain Arteriovenous Malformations and suggests a potential role of PLOD2 in brain Arteriovenous Malformations pathophysiology. PMID: 28279775
    7. FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2. PMID: 27298363
    8. Elevated fasting and postprandial C-terminal telopeptide after Roux-en-Y gastric bypass confers an increased risk of bone loss on recipients. PMID: 27555664
    9. PLOD2, which is associated with the stiffness of the extracellular matrix, was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC PMID: 27310702
    10. The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology. PMID: 27803159
    11. Results show that miR-26a and miR-26b were significantly downregulated in renal cell carcinoma clinical specimens and appeared to function as tumor suppressors through regulation of collagen cross-linking enzymes, LOXL2 and PLOD2, both of which function as oncogenes in this disease. PMID: 26983694
    12. findings reveal that TGFbeta1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 downstream co-activators and epigenetic modifications PMID: 26432637
    13. LH2 enhances the metastatic properties of tumor cells and functions as a regulatory switch that controls the relative abundance of biochemically distinct types of collagen cross-links in the tumor stroma. PMID: 25664850
    14. TGFbeta induced PLOD2/LH2 expression in human synovial osteoarthritic fibroblasts through ALK5 signaling. PMID: 24192939
    15. data indicate that HIF-1alpha controls sarcoma metastasis through PLOD2-dependent collagen modification and organization in primary tumors PMID: 23906982
    16. Infrapatellar fat pad contributeS to the development of synovial fibrosis in the knee joint by increasing collagen production, PLOD2 expression, cell proliferation, and cell migration. PMID: 23666869
    17. PLOD2 in addition to causing BS is also associated with AR-OI phenotypes of variable severity PMID: 22689593
    18. PLOD2 is a potential novel prognostic factor for HCC patients following surgery. PMID: 22098155
    19. Fox-2 plays an integral role in the regulation of LH2 splicing, and decrease in LH2 mRNA in primary scleroderma cells may suggest a novel approach to strategies directed against scleroderma. PMID: 20131247
    20. PLOD2 has a important role in fibrotic processes PMID: 12881513
    21. a boy who had congenital contractures with pterygia at birth and severe OI-like osteopenia and multiple fractures and he was shown to be homozygous for a novel mutation leading to an Arg598His substitution in PLOD2 PMID: 15523624
    22. 3 patients with mixed phenotypes of Ehlers-Danlos Syndrome with decreased mRNAs for LH2 in skin fibroblasts; mutations not shown that could explain decreased expression; deficiency of LH2 may be caused by changes in other factors required for expression PMID: 15589118
    23. alternate transcripts of LH2 may have specificity for hydroxylation of lysines in either telopeptide or helical collagen domains, so their relative expression determines the type of cross-links formed, thereby affecting collagen strength PMID: 15694128
    24. Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced PLOD2 levels. PMID: 15955452
    25. Data show that lysyl hydroxylase 2(long) exerts a bimodal function on collagen alpha(I) synthesis in human dermal fibroblasts. PMID: 16934803
    26. TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2 PMID: 19110540
    27. Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of LH2. PMID: 19762917
    28. Characterization of Plod2 and Plod3 gene structure in mouse and comparison to PLOD1, PLOD2, and PLOD3 gene structure in human. PMID: 11334715

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  • 相關(guān)疾?。?/div>
    Bruck syndrome 2 (BRKS2)
  • 亞細胞定位：
    Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
  • 組織特異性：
    Highly expressed in pancreas and muscle. Isoform 1 and isoform 2 are expressed in the majority of the examined cell types. Isoform 2 is specifically expressed in skin, lung, dura and aorta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9082

    OMIM: 601865

    KEGG: hsa:5352

    STRING: 9606.ENSP00000282903

    UniGene: Hs.477866