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  4. Recombinant Human Protein LDOC1 (LDOC1)

Recombinant Human Protein LDOC1 (LDOC1)

  • 中文名稱：
    人LDOC1重組蛋白
  • 貨號(hào)：
    CSB-YP012851HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人LDOC1重組蛋白
  • 貨號(hào)：
    CSB-EP012851HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人LDOC1重組蛋白
  • 貨號(hào)：
    CSB-EP012851HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LDOC1重組蛋白
  • 貨號(hào)：
    CSB-BP012851HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LDOC1重組蛋白
  • 貨號(hào)：
    CSB-MP012851HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LDOC1
  • Uniprot No.：
  • 別名：
    BCUR1; Breast cancer up regulated 1; Breast cancer upregulated 1; Gm366; Ldoc1; LDOC1_HUMAN; Leucine zipper down regulated in cancer 1; Leucine zipper protein down regulated in cancer cells; Leucine zipper protein down regulated in cancer cells; Leucine zipper protein down-regulated in cancer cells; Mar7; Mart7; Protein LDOC1; RGD1565644
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-146
  • 氨基酸序列
    MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP VPFPETFNGE SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA EEWVVPYIEM DSPILGDYRA FLDEMKQCFG WDDDEDDDDE EEEDDY
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May have an important role in the development and/or progression of some cancers.
  • 基因功能參考文獻(xiàn)：
    1. that epigenetic silencing of LDOC1 in high-risk Group A ependymoma regulates tumor biology and drives inflammatory immune phenotype PMID: 28510691
    2. GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis. PMID: 27764577
    3. These finding of this study suggested that the hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with Klinefelter Syndrome. PMID: 27076087
    4. data show that LDOC1 is a tumor suppressor in osteosarcoma, and that it regulates metastasis of osteosarcoma cells. Furthermore, LDOC1 might be a valuable prognostic marker in osteosarcomas. PMID: 28240050
    5. Cigarette smoke-induced promoter methylation may contribute to LDOC1 downregulation, thereby conferring oncogenic features to oral cells. PMID: 26317789
    6. LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-kappaB activation in papillary thyroid carcinoma PMID: 26637328
    7. It has potential roles in apoptosis of well differentiated carcinoma without metastases and in neurodegeneration of Alzheimer's disease. PMID: 23775301
    8. Silencing of LDOC1 is a frequent event in cervical cancer and may be of interest as a molecular marker in cervical cancer. PMID: 24125169
    9. Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence. PMID: 23362108
    10. Letter/Case Report: LDOC1/PARP1 are down-regulated in melanoma with repeated in-transit metastases. PMID: 21986234
    11. The aim of this study was to evaluate the possible differential expression of LDOC1 mRNA in leucocytes of peripheral blood of Down's syndrome subjects. compared with the normal population. PMID: 22546831
    12. Over expression of LDOC1 may explain the clinical manifestation found in patients with cryptochidism and Digeorge anomaly. PMID: 21547351
    13. LDOC1 is dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases, and have identified a new splice variant, LDOC1S PMID: 21310924
    14. These observations suggest that LDOC1 is a novel regulator of NF-kappaB that can affect the PMA or TNF-alpha-mediated pathway to apoptosis through inhibition of NF-kappaB activation in BxPC3 pancreatic cancer cells. PMID: 12712434
    15. MZF-1 was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis PMID: 15670815

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    LDOC1 family
  • 組織特異性：
    Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6548

    OMIM: 300402

    KEGG: hsa:23641

    STRING: 9606.ENSP00000359557

    UniGene: Hs.45231