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  4. Recombinant Human Putative DNA repair and recombination protein RAD26-like (RAD26L)

Recombinant Human Putative DNA repair and recombination protein RAD26-like (RAD26L)

  • 中文名稱：
    人ERCC6L2重組蛋白
  • 貨號(hào)：
    CSB-YP729209HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ERCC6L2重組蛋白
  • 貨號(hào)：
    CSB-EP729209HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ERCC6L2重組蛋白
  • 貨號(hào)：
    CSB-EP729209HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ERCC6L2重組蛋白
  • 貨號(hào)：
    CSB-BP729209HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ERCC6L2重組蛋白
  • 貨號(hào)：
    CSB-MP729209HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ERCC6L2
  • Uniprot No.：
  • 別名：
    C9orf102; Chromosome 9 open reading frame 102; excision repair cross-complementing rodent repair deficiency; complementation group 6-like 2; FLJ37706; MGC30192; MGC43364; Putative DNA repair and recombination protein RAD26-like; putative repair and recombination helicase RAD26L; RAD26_HUMAN; Rad26l; RAD26L hypothetical protein; SR278; stretch responsive protein 278
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-712
  • 氨基酸序列
    MQPGSAPPPG RMDPSAPQPR AETSGKDIWH PGERCLAPSP DNGKLCEASI KSITVDENGK SFAVVLYADF QERKIPLKQL QEVKFVKDCP RNLIFDDEDL EKPYFPNRKF PSSSVAFKLS DNGDSIPYTI NRYLRDYQRE GTRFLYGHYI HGGGCILGDD MGLGKTVQVI SFLAAVLHKK GTREDIENNM PEFLLRSMKK EPLSSTAKKM FLIVAPLSVL YNWKDELDTW GYFRVTVLHG NRKDNELIRV KQRKCEIALT TYETLRLCLD ELNSLEWSAV IVDEAHRIKN PKARVTEVMK ALKCNVRIGL TGTILQNNMK ELWCVMDWAV PGLLGSGTYF KKQFSDPVEH GQRHTATKRE LATGRKAMQR LAKKMSGWFL RRTKTLIKDQ LPKKEDRMVY CSLTDFQKAV YQTVLETEDV TLILQSSEPC TCRSGQKRRN CCYKTNSHGE TVKTLYLSYL TVLQKVANHV ALLQAASTSK QQETLIKRIC DQVFSRFPDF VQKSKDAAFE TLSDPKYSGK MKVLQQLLNH CRKNRDKVLL FSFSTKLLDV LQQYCMASGL DYRRLDGSTK SEERLKIVKE FNSTQDVNIC LVSTMAGGLG LNFVGANVVV LFDPTWNPAN DLQAIDRAYR IGQCRDVKVL RLISLGTVEE IMYLRQIYKQ QLHCVVVGSE NAKRYFEAVQ GSKEHQGELF GIHNLFKFRS QGSCLTKDIL EV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in early DNA damage response.
  • 基因功能參考文獻(xiàn)：
    1. ERCC6L2-associated disorder has recently been described. We identified an additional case through whole-exome sequencing. At the age of 9 years, the patient underwent whole exome sequencing and was discovered to have a homozygous stop mutation in ERCC6L2 (NCBI RefSeq NG_034107.1), c.1687C>T (p.Arg563*). PMID: 29633571
    2. The inherited bone marrow failure syndrome caused by biallelic variants in ERCC6L2 can be considered as a primary transcription deficiency rather than a DNA repair defect PMID: 29987015
    3. Hebo is ubiquitously expressed, localized in the nucleus, and rapidly recruited to DNAdsb's in an NBS1-dependent manner. PMID: 27185855
    4. These observations identify a distinct bone-marrow-failure syndrome due to mutations in ERCC6L2, a gene implicated in DNA repair and mitochondrial function. PMID: 24507776
  • 相關(guān)疾?。?/div>
    Bone marrow failure syndrome 2 (BMFS2)
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 組織特異性：
    Expressed in bone marrow (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26922

    OMIM: 615667

    KEGG: hsa:375748

    STRING: 9606.ENSP00000288985

    UniGene: Hs.432364