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  4. Recombinant Human Serine/threonine-protein kinase 16 (STK16)

Recombinant Human Serine/threonine-protein kinase 16 (STK16)

  • 中文名稱：
    人STK16重組蛋白
  • 貨號：
    CSB-EP022835HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    STK16
  • Uniprot No.：
  • 別名：
    EDPK; F52; FLJ39635; hPSK; KRCT; MGC16211; MPSK; MPSK1; Myristoylated and palmitoylated serine/threonine protein kinase; Myristoylated and palmitoylated serine/threonine-protein kinase; PKL12 ; Protein kinase expressed in day 12 fetal liver ; Protein kinase Krct; Protein kinase PKL12; Serine/threonine kinase 16 ; Serine/threonine protein kinase 16; Serine/threonine-protein kinase 16; Stk16; STK16_HUMAN; TGF beta stimulated factor 1; TGF-beta-stimulated factor 1; TGFB stimulated factor 1; Transforming growth factor beta stimulated factor 1; TSF-1; TSF1; Tyrosine protein kinase STK16
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    61.5kDa
  • 表達區(qū)域：
    1-305aa
  • 氨基酸序列
    GHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal GST-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
  • 基因功能參考文獻：
    1. we revealed STK16 as a novel actin binding protein that resides in the Golgi, which regulates actin dynamics to control Golgi structure and participate in cell cycle progression. PMID: 28294156
    2. MAL2 and STK16 function to sort secretory soluble cargo into the constitutive secretory pathway in hepatocytes. PMID: 25084525
    3. The Endogenous STK16 subcellular localization was evaluated by indirect immunofluorescence in NRK cells, demonstrating a Golgi-associated pattern that appears to be independent of signals provided by integrin pathways. PMID: 16310770
  • 亞細胞定位：
    Cytoplasm, perinuclear region. Membrane; Lipid-anchor.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitously expressed at very low levels.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11394

    OMIM: 604719

    KEGG: hsa:8576

    STRING: 9606.ENSP00000379964

    UniGene: Hs.153003