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  4. Recombinant Human Serine/threonine-protein kinase LMTK2 (LMTK2), partial

Recombinant Human Serine/threonine-protein kinase LMTK2 (LMTK2), partial

  • 中文名稱：
    人LMTK2重組蛋白
  • 貨號：
    CSB-YP812882HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LMTK2重組蛋白
  • 貨號：
    CSB-EP812882HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LMTK2重組蛋白
  • 貨號：
    CSB-EP812882HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LMTK2重組蛋白
  • 貨號：
    CSB-BP812882HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LMTK2重組蛋白
  • 貨號：
    CSB-MP812882HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LMTK2
  • Uniprot No.：
  • 別名：
    AATYK 2; AATYK2; Apoptosis associated tyrosine kinase 2; Apoptosis-associated tyrosine kinase 2; Brain enriched kinase; Brain-enriched kinase; BREK; CDK5/p35 regulated kinase; CDK5/p35-regulated kinase; CPRK; cyclin-dependent kinase 5/p35-regulated kinase; FLJ46659; hBREK; KIAA1079; Kinase phosphatase inhibitor 2; Kinase/phosphatase/inhibitor 2; KPI 2; KPI-2; KPI2; Lemur tyrosine kinase 2; LMR 2; LMR2; LMTK 2; Lmtk2; LMTK2_HUMAN; PPP1R100; protein phosphatase 1; regulatory subunit 100; Serine/threonine protein kinase KPI 2; Serine/threonine protein kinase KPI2; Serine/threonine protein kinase LMTK 2; Serine/threonine protein kinase LMTK2; Serine/threonine-protein kinase KPI-2; Serine/threonine-protein kinase LMTK2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Phosphorylates PPP1C, phosphorylase b and CFTR.
  • 基因功能參考文獻(xiàn)：
    1. both BIM and BCL2 proteins are regulated by LMTK2 in a GSK3beta- and PP1A-dependent manner. PMID: 28040547
    2. Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life. PMID: 26559041
    3. Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor transcriptional activity. PMID: 26008968
    4. Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. PMID: 24727471
    5. The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm. PMID: 23114966
    6. We describe a new signalling pathway within the nervous system that links cdk5/p35 with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction PMID: 22220831
    7. Low LMTK2 expression is associated with the development of prostate cancer. PMID: 20569440
    8. KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes PMID: 12393858
    9. Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5/p35; Cdk5/p35 inhibits cprk activity PMID: 12832520
    10. BREK, Brain Enriched Kinase, is a new member of the family of protein serine/threonine kinases; plays important roles in NGF-TrkA signalling in the brain [BREK] PMID: 15005709
    11. role of the segment KLHY in binding with protein phosphatase 1 PMID: 16428298
    12. Myosin VI and LMTK2 are required for the transport of cargo, such as the Transferrin Receptor, from early endosomes to the endocytic recycling compartment. PMID: 18029400
    13. Results show that BREK is critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes and also suggest an involvement of myosin VI in this pathway. PMID: 18429820

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 組織特異性：
    Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17880

    OMIM: 610989

    KEGG: hsa:22853

    STRING: 9606.ENSP00000297293

    UniGene: Hs.444179