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  4. Recombinant Human Spermatid nuclear transition protein 1 (TNP1)

Recombinant Human Spermatid nuclear transition protein 1 (TNP1)

  • 中文名稱：
    人TNP1重組蛋白
  • 貨號：
    CSB-YP024018HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TNP1重組蛋白
  • 貨號：
    CSB-EP024018HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TNP1重組蛋白
  • 貨號：
    CSB-EP024018HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TNP1重組蛋白
  • 貨號：
    CSB-BP024018HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TNP1重組蛋白
  • 貨號：
    CSB-MP024018HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TNP1
  • Uniprot No.：
  • 別名：
    Spermatid nuclear transition protein 1; Spermatid nuclear transition protein1; STP 1; STP-1; STP1; STP1_HUMAN; TNP 1; TNP1; TP 1; TP-1; TP1; Transition protein 1 (during histone to protamine replacement); Transition protein1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-55
  • 氨基酸序列
    STSRKLKSHGMRRSKSRSPHKGVKRGGSKRKYRKGNLKSRKRGDDANRNYRSHL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
  • 基因功能參考文獻：
    1. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
    2. frequency of the haplotype GCG (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level. PMID: 20522125
    3. a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility PMID: 16291974
    4. We found significantly lower levels of HILS1, TNP1, and TNP2 transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men. PMID: 17852044
    5. The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos. PMID: 18292840
    6. The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men. PMID: 18727729

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  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Nuclear transition protein 1 family
  • 組織特異性：
    Expressed by spermatids (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11951

    OMIM: 190231

    KEGG: hsa:7141

    STRING: 9606.ENSP00000236979

    UniGene: Hs.3017