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  4. Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2), partial

Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2), partial

In Stock
  • 中文名稱：
    人SUCLG2重組蛋白
  • 貨號：
    CSB-EP846636HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP846636HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SUCLG2.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP846636HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SUCLG2.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    SUCLG2
  • Uniprot No.：
  • 別名：
    EC 6.2.1.4 ; G BETA; GBETA; GTP specific succinyl-CoA synthetase beta subunit; GTP specific succinyl-CoA synthetase subunit beta; GTP-specific succinyl-CoA synthetase subunit beta; mitochondrial; SCS betaG ; SCS-betaG; SUCB2_HUMAN; Succinate CoA ligase GDP forming beta subunit; Succinate-Coenzyme A ligase; GDP-forming; beta subunit; Succinyl CoA ligase GDP forming beta chain mitochondrial ; Succinyl CoA synthetase betaG chain; Succinyl-CoA ligase [GDP-forming] subunit beta; Succinyl-CoA ligase [GDP-forming] subunit beta; mitochondrial; Succinyl-CoA synthetase beta-G chain; SUCLG2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    56.3kDa
  • 表達(dá)區(qū)域：
    49-423aa
  • 氨基酸序列
    MSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  • 基因功能參考文獻(xiàn)：
    1. SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933
    2. The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism PMID: 25370487
    3. SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease. PMID: 25027320
    4. Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome. PMID: 21295139
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Succinate/malate CoA ligase beta subunit family, GTP-specific subunit beta subfamily
  • 組織特異性：
    Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11450

    OMIM: 603922

    KEGG: hsa:8801

    STRING: 9606.ENSP00000419325

    UniGene: Hs.644919