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  4. Recombinant Human Synphilin-1 (SNCAIP), partial

Recombinant Human Synphilin-1 (SNCAIP), partial

  • 中文名稱：
    人SNCAIP重組蛋白
  • 貨號(hào)：
    CSB-YP896546HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人SNCAIP重組蛋白
  • 貨號(hào)：
    CSB-EP896546HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人SNCAIP重組蛋白
  • 貨號(hào)：
    CSB-EP896546HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SNCAIP重組蛋白
  • 貨號(hào)：
    CSB-BP896546HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SNCAIP重組蛋白
  • 貨號(hào)：
    CSB-MP896546HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SNCAIP
  • Uniprot No.：
  • 別名：
    Alpha synuclein interacting protein; Alpha-synuclein-interacting protein; MGC39814; SNCAIP; SNCAP_HUMAN; Sph1; Synphilin-1; Synphilin1; Synuclein alpha interacting protein (synphilin); Synuclein alpha interacting protein; SYPH 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
  • 基因功能參考文獻(xiàn)：
    1. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain. PMID: 26465922
    2. Synphilin-1 binds ATP, but not CTP. PMID: 25545246
    3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity. PMID: 24829096
    4. Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity PMID: 22828940
    5. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation. PMID: 20849899
    6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease. PMID: 21344240
    7. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation. PMID: 20816781
    8. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. PMID: 21103907
    9. Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition. PMID: 20604806
    10. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD. PMID: 19730898
    11. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease PMID: 19857556
    12. alpha-synuclein-synphilin-1 interaction significantly promotes the formation of cytoplasmic alpha-synuclein inclusions, which may have implications for Lewy body formation in neural cells PMID: 19762560
    13. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. PMID: 11958831
    14. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
    15. a causative role of the R621C mutation in the synphilin-1 gene in Parkinson's disease PMID: 12761037
    16. Changes in synuclein expression presage neurodegeneration in a Drosophila model of Parkinson disease. PMID: 12915459
    17. Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release PMID: 14506261
    18. role of aggresomes in cell viability was addressed in the context of over-expressing alpha-synuclein and its interacting partner synphilin-1 PMID: 14627698
    19. Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies. PMID: 14645218
    20. role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease PMID: 15322916
    21. Parkin is a dual-function ubiquitin ligase. K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with Parkinson disease. PMID: 15728840
    22. We confirm that synphilin-1 and parkin are components of majority of Lewy Bodies in Parkinson's disease and that both proteins are susceptible to proteasomal degradation. PMID: 15894486
    23. GSK3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH PMID: 16174773
    24. Synphilin-1A may contribute to neuronal degeneration in alpha-synuclein mutations and provides insights into the role of inclusion bodies in neurodegenerative disorders. PMID: 16595633
    25. These results suggest that NUB1 indeed targets synphilin-1 to the proteasome for its efficient degradation, which, because of the resultant reduction in synphilin-1, suppresses the formation of synphilin-1-positive inclusions. PMID: 16877356
    26. a novel specific interaction of synphilin-1 with the regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like intracytoplasmic inclusions PMID: 17327361
    27. These findings suggest that parkin and synphilin-1 isoform expression changes play a significant role in the pathogenesis of LB diseases. PMID: 17467279
    28. review:Isoform Synphilin-1A inclusions recruit both alpha-synuclein and synphilin-1. Aggregation of synphilin-1 and synphilin-1A seems to be protective to cells PMID: 17982729
    29. specific effects of C621 mutant synphilin-1 on gene expression that correlate with its role as a susceptibility factor in Parkinson's disease PMID: 18292964
    30. All four alpha-synuclein isoforms were affected in dementia with LB (Lewy bodies), most parkin transcript variants in common LB disease, and all synphilin-1 isoforms in Parkinson disease. PMID: 18335262
    31. We found no evidence for association between genetic variability in synphilin-1 and Parkinson's disease PMID: 18366718
    32. translocation to aggresomes required a special aggresome-targeting signal within the sequence of synphilin 1, an ankyrin-like repeat domain. PMID: 18635553
    33. Synphilin-1 might be involved in motor function, and its accumulation in the central nervous system can cause motor impairments. PMID: 18782602
    34. synphilin-1A has a novel role as a regulator of SIAH activity, modulating alpha-synuclein, and formation of Lewy body-like inclusions PMID: 19224863

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  • 相關(guān)疾病：
    Parkinson disease (PARK)
  • 亞細(xì)胞定位：
    Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
  • 組織特異性：
    Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11139

    OMIM: 168600

    KEGG: hsa:9627

    STRING: 9606.ENSP00000261368

    UniGene: Hs.426463