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  4. Recombinant Human T cell receptor alpha chain constant (TRAC)

Recombinant Human T cell receptor alpha chain constant (TRAC)

In Stock
  • 中文名稱：
    人TRAC重組蛋白
  • 貨號(hào)：
    CSB-YP024144HU
  • 規(guī)格：
    ￥1500
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    TRAC; TCRA; T cell receptor alpha constant
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length
  • 來(lái)源：
    Yeast
  • 分子量：
    17.9kDa
  • 表達(dá)區(qū)域：
    1-142aa
  • 氨基酸序列
    PNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    Intact human T cell receptor alpha constant (TRAC) cDNA (1-142aa) with an N-terminal 6xHis-tag was expressed in the yeast. The forming protein is the recombinant full-length human TRAC protein. The purity of this protein is greater than 90% determined by SDS-PAGE. Under reducing conditions, the gel showed a molecular weight band of about 16 kDa. This recombinant TRAC protein can be used as the immunogen for antibody synthesis. Besides, it also may be applied in the studies of TRAC-related immunology.

    The extracellular region of αβ T cell receptors (TCRs) is made up of an α chain and a β chain, each containing Ig-like variable and constant domains. TRAC, the TCR Cα domain, is significant in differing from the classical IgC1 domain. Substantial evidence indicated that TRAC interfaces with CD3. Mutagenesis has demonstrated that the interactions of CD3δ? and CD3γ? subunits with the TcR Cα and Cβ domains, respectively, contribute to the stability and function of the TCR–CD3 signaling complex. Gijs I. van Boxel etc. concluded that the TCR Cα domain can also adopt two very different stable conformations, a fundamental property that is potentially central to TCR function and that the TCR Cα domain may facilitate the "β-strand slippage."

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
  • 相關(guān)疾?。?/div>
    Immunodeficiency 7 (IMD7)
  • 亞細(xì)胞定位：
    Cell membrane.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12029

    OMIM: 186880

    UniGene: Hs.74647