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  4. Recombinant Human Transmembrane protein 132D (TMEM132D), partial

Recombinant Human Transmembrane protein 132D (TMEM132D), partial

  • 中文名稱：
    人TMEM132D重組蛋白
  • 貨號(hào)：
    CSB-YP023702HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TMEM132D重組蛋白
  • 貨號(hào)：
    CSB-EP023702HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TMEM132D重組蛋白
  • 貨號(hào)：
    CSB-EP023702HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TMEM132D重組蛋白
  • 貨號(hào)：
    CSB-BP023702HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TMEM132D重組蛋白
  • 貨號(hào)：
    CSB-MP023702HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TMEM132D
  • Uniprot No.：
  • 別名：
    TMEM132D; HBE120; KIAA1944; MOLT; Transmembrane protein 132D; Mature oligodendrocytes transmembrane protein; Mature OL transmembrane protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May serve as a cell-surface marker for oligodendrocyte differentiation.
  • 基因功能參考文獻(xiàn)：
    1. Thus, GPC6 and TMEM132D may serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis. PMID: 26448945
    2. TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotionl signals PMID: 25974322
    3. Enhanced amygdala gray matter volumes and anxiety-related (but not panic-specific) personality profiles are found in healthy normal carriers of the rs11060369 AA TMEM132D genotype. PMID: 24495968
    4. data suggest that not only common but also putatively functional and/or rare variants within TMEM132D might contribute to the risk to develop anxiety disorders PMID: 22911938
    5. TMEM132D was first identified as a possible candidate gene for panic disorder in a genome-wide association study conducted at the Max Planck Institute of Psychiatry in Munich. PMID: 22948381
    6. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. PMID: 21784300
    7. TMEM132D may be an important new candidate gene for PD as well as more generally for anxiety-related behavior. PMID: 20368705

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM132 family
  • 組織特異性：
    Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29411

    OMIM: 611257

    KEGG: hsa:121256

    STRING: 9606.ENSP00000408581

    UniGene: Hs.507268