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  4. Recombinant Human p53-regulated apoptosis-inducing protein 1 (TP53AIP1)

Recombinant Human p53-regulated apoptosis-inducing protein 1 (TP53AIP1)

  • 中文名稱：
    人TP53AIP1重組蛋白
  • 貨號：
    CSB-EP884624HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    p53 regulated apoptosis inducing protein 1; p53-regulated apoptosis-inducing protein 1; P53AIP 1; p53AIP1; TP53AIP 1; TP53AIP1; TPIP1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of BC069399
  • 來源：
    E.coli
  • 分子量：
    38.3kDa
  • 表達(dá)區(qū)域：
    1-108aa
  • 氨基酸序列
    MGSSSEVSFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSPCSENRDGLLPATAPGRLCSHRGADIPSFQTHQDPVTASGSSELHADCPQFRALDRAGN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal GST-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May play an important role in mediating p53/TP53-dependent apoptosis.
  • 基因功能參考文獻(xiàn)：
    1. results show that constitutional truncating TP53AIP1 mutations predispose to CMM in the French population PMID: 29359367
    2. Data indicate that p53-regulated apoptosis-inducing protein 1 (p53AIP1) inhibits the proliferation of PC-3M cells, arrests cell cycle at S/G2-M phase, decreases the abilities of invasion and migration and promotes cell apoptosis. PMID: 25108434
    3. These studies indicate the critical role of p53AIP1 under DNA damaging stresses for cell fate determination in rheumatoid arthritis-fibroblast-like synovioctes containing the p53R248Q mutation. PMID: 24316591
    4. Apak competes with p53 for binding to inhibit p53AIP1 expression. PMID: 22334068
    5. large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition PMID: 22457820
    6. p53AIP1 regulates the mitochondrial apoptotic pathway. PMID: 12019168
    7. The expression of Ki67 and p53 in various forms of leukoplakia point to the increasing instability of the genome in parallel with the severity of leukoplakia. PMID: 14707453
    8. expression of the p53 mutant, R248Q, in liver cancer cells may enhance their drug resistance and upregulation of P-glycoprotein activity may contribute to this protective effect. PMID: 15004724
    9. Roscovitine induced up-regulation of p53AIP1 protein and the depolarization of mitochondrial potential. PMID: 15657359
    10. p53AIP1 gene is important for non-small cell lung cancer progression and may be a possible prognostic marker PMID: 17851056
    11. Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection. PMID: 18277906
    12. Data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population. PMID: 19228369

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  • 亞細(xì)胞定位：
    Mitochondrion.
  • 組織特異性：
    Only found to be expressed in thymus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29984

    OMIM: 605426

    KEGG: hsa:63970

    STRING: 9606.ENSP00000432743

    UniGene: Hs.160953