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  4. Recombinant Human papillomavirus type 18 Protein E7 (E7)

Recombinant Human papillomavirus type 18 Protein E7 (E7)

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  • 中文名稱：
    Recombinant Human papillomavirus type 18 Protein E7(E7)
  • 貨號：
    CSB-YP361948HMN
  • 規(guī)格：
    ￥1500
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    E7; Protein E7
  • 種屬：
    Human papillomavirus type 18
  • 蛋白長度：
    Full Length
  • 來源：
    Yeast
  • 分子量：
    14.0 kDa
  • 表達區(qū)域：
    1-105aa
  • 氨基酸序列
    MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：
        乳頭瘤病毒（HPV）是一組常見的病毒，其中HPV-18型是引發(fā)宮頸癌等癌癥的主要病毒株之一。人乳頭瘤病毒18型蛋白E7（E7）是HPV感染中的一個關(guān)鍵蛋白，通過干擾宿主細胞的調(diào)控機制，參與細胞轉(zhuǎn)型和癌癥的發(fā)生。
        華美生物的重組人HPV18型E7蛋白是通過酵母表達系統(tǒng)表達的全長蛋白，包括E7蛋白的完整序列。該產(chǎn)品可用于體外實驗、蛋白結(jié)合研究和功能性實驗。通過研究E7蛋白，可以深入了解HPV感染引發(fā)的宮頸癌等癌癥的分子機制。E7蛋白與宿主細胞中的關(guān)鍵調(diào)控分子相互作用，影響細胞周期、凋亡等關(guān)鍵生物學過程。
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

問答及客戶評論

■ 常見問題解答
Q:

Can you please provide the concentration of CSB-EP361948HMN; Recombinant Human papillomavirus type 18 Protein E7 (E7) to me?

A:
Thanks for your inquiry. According the the record, this protein is provdied as lyophilized form.
Lyophilized from a 0.2 μm filtered 10 mM Tris-HCl, 1 mM EDTA, pH 8.0.
The volume before lyophilization is 200ul/vial.

靶點詳情

  • 功能：
    Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
  • 亞細胞定位：
    Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Papillomaviridae E7 protein family