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Recombinant Mouse CCAAT/enhancer-binding protein epsilon (Cebpe)

  • 中文名稱：
    Recombinant Mouse CCAAT/enhancer-binding protein epsilon(Cebpe)
  • 貨號(hào)：
    CSB-YP761372MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse CCAAT/enhancer-binding protein epsilon(Cebpe)
  • 貨號(hào)：
    CSB-EP761372MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse CCAAT/enhancer-binding protein epsilon(Cebpe)
  • 貨號(hào)：
    CSB-EP761372MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse CCAAT/enhancer-binding protein epsilon(Cebpe)
  • 貨號(hào)：
    CSB-BP761372MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse CCAAT/enhancer-binding protein epsilon(Cebpe)
  • 貨號(hào)：
    CSB-MP761372MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cebpe
  • Uniprot No.：
  • 別名：
    Cebpe; Gm294CCAAT/enhancer-binding protein epsilon; C/EBP epsilon
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-281
  • 氨基酸序列
    MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE EQLLSDLFAM KPTPEARSLK GPGAPSFPHY LPADPRPFAY PSHTFGPDRK ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTSRGSYNP LQYQVAHCGQ TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRNRV DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
  • 基因功能參考文獻(xiàn)：
    1. study suggests that the myeloid specific factor C/EBPepsilon is involved in systemic lipid metabolism and that silencing of C/EBPepsilon could decrease the development of atherosclerosis. PMID: 24489659
    2. Data show that macrophages from bbee compared to single knockout mice revealed decreased expression of essential immune response-related genes and networks. PMID: 21072215
    3. in the absence of CCAAT enhancer binding protein epsilon (C/EBPepsilon), there is not only incomplete differentiation of granulocytes, but myelopoiesis is disrupted and neutrophils have abnormal chemotaxis PMID: 19925846
    4. C/EBP epsilon gene as an important transcription factor required for normal function and development of macrophages. PMID: 11861297
    5. C/EBPepsilon interacts with Rb and E2F1 during granulocytic differentiation PMID: 12947005
    6. in the later stages of myeloid development, MMP8 and other SGP genes are coordinately upregulated, and members of the C/EBP family, in particular C/EBPalpha and C/EBPepsilon, play specific and unique roles in upregulating their expression PMID: 15661397
    7. Gfi-1 down-regulates C/EBPepsilon expression; increased expression of C/EBPepsilon as a consequence of loss of Gfi-1 function may be deleterious to the proliferation and survival of early myeloid cells PMID: 16500901
    8. the N terminus of C/EBPepsilon is solely responsible for most aspects of myeloid differentiation, and these events are differentially affected by c-Myc PMID: 16531405
    9. the requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo. PMID: 17483073
    10. The type IV isoform of PML interacted with PU.1, promoted its association with p300, and then enhanced PU.1-induced transcription and granulocytic differentiation and PU.1 directly activates the transcription of the C/EBPepsilon gene. PMID: 17562868
    11. Phosphorylation of PML was required for stimulating C/EBP epsilon-dependent transcription and accelerating C/EBP epsilon-induced granulocytic differentiation. PMID: 17989716
    12. Lbr, under transcriptional regulation of C/EBPepsilon, is necessary for morphological but not necessarily functional granulocyte PMID: 18621876

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, C/EBP subfamily
  • 數(shù)據(jù)庫(kù)鏈接：