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  4. Recombinant Mouse Carboxylesterase 1C (Ces1c), partial

Recombinant Mouse Carboxylesterase 1C (Ces1c), partial

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  • 中文名稱：
    Recombinant Mouse Carboxylesterase 1C(Ces1c),partial
  • 貨號：
    CSB-YP338557MO
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP338557MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Ces1c.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP338557MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Ces1c.
    • The purity of Ces1c was greater than 95% as determined by SEC-HPLC
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC.
  • 基因名：
    Ces1c
  • Uniprot No.：
  • 別名：
    Carboxylesterase 1C; Ces N; Ces1c; Ee 1; Ee 4; Ee1; Es N; Es1; Es4; EsN; EST1C_MOUSE; Esterase 1; Liver carboxylesterase N; Lung surfactant convertase; PES-N; PESN
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    Yeast
  • 分子量：
    60.6kDa
  • 表達(dá)區(qū)域：
    19-550aa
  • 氨基酸序列
    HSLLPPVVDTTQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSSAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPKAPEEILAEKSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFGDIFFGIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFFVFGAPLLKEGASEEETNLSKMVMKFWANFARNGNPNGEGLPHWPEYDEQEGYLQIGATTQQAQRLKAEEVAFWTELLAKNPPETDPTEH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：
        小鼠羧酸酯酶1C（Ces1c）是一種重要的絲氨酸水解酶家族成員，主要分布于人體肝臟中，腸道組織中幾乎沒有。在小鼠中，Ces1c的缺失會影響藥物和脂質(zhì)代謝及穩(wěn)態(tài)。值得注意的是，雖然Ces1c在小鼠中起著重要的作用，但在某些情況下，如藥物開發(fā)中，Ces1c的缺失可能會帶來一些問題。例如，Ces1c的缺失可能會導(dǎo)致藥物在小鼠體內(nèi)的代謝和穩(wěn)態(tài)受到影響。因此，在進(jìn)行藥物開發(fā)時，需要考慮到Ces1c的作用，以便更好地理解和利用其特性。
        華美生物的小鼠羧酸酯酶1C（Ces1c）重組蛋白，由酵母表達(dá)系統(tǒng)表達(dá)，表達(dá)區(qū)域為1-441aa，具備高純度高穩(wěn)定性等特點，助您進(jìn)行相關(guān)科學(xué)研究。
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.
  • 基因功能參考文獻(xiàn)：
    1. Phospho-non-steroidal anti-inflammatory drugs hydrolysis in wild-type mouse plasma was 6-530-fold higher than that in the plasma of Ces1c-/- mice. PMID: 25392229
    2. Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels PMID: 25285996
    3. These results identify and characterize ES1 as a novel transcriptional regulator of GHR gene expression. PMID: 21659478
  • 亞細(xì)胞定位：
    Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 組織特異性：
    Expressed in lung, kidney and liver.
  • 數(shù)據(jù)庫鏈接：