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  4. Recombinant Mouse Cytoplasmic FMR1-interacting protein 1 (Cyfip1), partial

Recombinant Mouse Cytoplasmic FMR1-interacting protein 1 (Cyfip1), partial

  • 中文名稱：
    Recombinant Mouse Cytoplasmic FMR1-interacting protein 1(Cyfip1) ,partial
  • 貨號：
    CSB-YP742490MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytoplasmic FMR1-interacting protein 1(Cyfip1) ,partial
  • 貨號：
    CSB-EP742490MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytoplasmic FMR1-interacting protein 1(Cyfip1) ,partial
  • 貨號：
    CSB-EP742490MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytoplasmic FMR1-interacting protein 1(Cyfip1) ,partial
  • 貨號：
    CSB-BP742490MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cytoplasmic FMR1-interacting protein 1(Cyfip1) ,partial
  • 貨號：
    CSB-MP742490MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cyfip1; Kiaa0068; Shyc; Sra1Cytoplasmic FMR1-interacting protein 1; Specifically Rac1-associated protein 1; Sra-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
  • 基因功能參考文獻：
    1. These results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction. PMID: 28183735
    2. In Cyfip1-deficient mice, parental origin determines the impairment of synaptic functions and behavior. PMID: 26474913
    3. Data suggest that MAP kinase-interacting kinases (Mnk1, Mnk2) regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of cytoplasmic eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1. PMID: 25588502
    4. CYFIP2 is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior. PMID: 24357318
    5. This study demonistrated that CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation. PMID: 24050404
    6. haploinsufficiency of Cyfip1 mimics key aspects of the phenotype of Fmr1 knockout mice and are consistent with the hypothesis that these effects are mediated by interaction of Cyfip1 and Fmrp in regulating activity-dependent translation. PMID: 22900020
    7. indentification on mouse chromosome 7C PMID: 14508708
    8. Sra-1 and Nap1 are constitutive and essential components of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly. PMID: 14765121
    9. The translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1. PMID: 18805096

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    CYFIP family
  • 組織特異性：
    Highly expressed in embryonic and adult developing nervous system.
  • 數(shù)據(jù)庫鏈接：