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  4. Recombinant Mouse Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), partial

Recombinant Mouse Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), partial

  • 中文名稱：
    小鼠Gpam重組蛋白
  • 貨號：
    CSB-YP720254MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gpam重組蛋白
  • 貨號：
    CSB-EP720254MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Gpam重組蛋白
  • 貨號：
    CSB-EP720254MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gpam重組蛋白
  • 貨號：
    CSB-BP720254MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gpam重組蛋白
  • 貨號：
    CSB-MP720254MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Gpam
  • Uniprot No.：
  • 別名：
    Gpam; Gpat1; Glycerol-3-phosphate acyltransferase 1; mitochondrial; GPAT-1; EC 2.3.1.15; P90
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
  • 基因功能參考文獻(xiàn)：
    1. Silencing of GPAT1 by gpat1 siRNA transfection reduced glucosamine-mediated anti-apoptosis in mouse embryonic stem cells and reduced mammalian target of rapamycin phosphorylation. PMID: 27010859
    2. GPAT1, but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation. PMID: 23908354
    3. GPAT1 deletion is capable of reducing the number of new T cells produced via alterations in membrane receptor function. PMID: 23179391
    4. In the neonatal liver, DNA methylation of the Gpam promoter inhibited recruitment of the lipogenic transcription factor SREBP-1c, whereas in the adult, decreased DNA methylation resulted in active chromatin conformation, allowing recruitment of SREBP-1c. PMID: 22721968
    5. It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis. PMID: 22215515
    6. Sterol regulatory element binding protein 1 mediated induction of hepatic steatosis in obese mice requires Gpat1. PMID: 20200319
    7. Data confirm the role of mitochondrial glycerol-3-phosphate acyltransferase (GPAT) in the synthesis of triacylglycerol, in the fatty acid content of triacylglycerol and cholesterol esters, and in the positioning of specific fatty acids in phospholipids. PMID: 12417724
    8. results support the concept that increased hepatic mtGPAT activity associated with obesity positively contributes to lipid disorders by reducing oxidative processes and promoting de novo glycerolipid synthesis. PMID: 15102885
    9. mtGPAT1 is essential for normal acyl-CoA metabolism, and that the absence of hepatic mtGPAT1 results in the partitioning of fatty acids away from triacylglycerol synthesis and toward oxidation and ketogenesis PMID: 15878874
    10. Increased hepatic mtGPAT activity associated with obesity and insulin resistance MAY contribute to increased TAG biosynthesis and inhibition of fatty acid oxidation, responses that would promote hepatic steatosis and dyslipidemia. PMID: 16507761
    11. acute reduction of mtGPAT1 in liver of ob/ob mice reduces TAG synthesis, which points to a role for mtGPAT1 in the correction of obesity and related disorders PMID: 16935266
    12. Gpat1-/- liver exhibits increased oxidative stress and sensitivity of the mitochondrial permeability transition pore, and a balanced increase in apoptosis and proliferation. PMID: 17258706
    13. GPAT1 contributes significantly to cardiomyocyte triacylglycerol synthesis during lipogenic or high-fat diets and influences the incorporation of 20:4n6 into heart phospholipids. PMID: 18522808
    14. a novel link between GPAT-1 and changes in T-lymphocyte function PMID: 18971390
    15. Our results indicate differential roles of the two promoters in the regulation of hepatic GPAT1 gene expression in mice. PMID: 18983939
    16. Data indicate that a lack of GPAT1 activity affects both innate and adaptive immune mechanisms. Innate mechanisms may be affected by altered membrane composition or host redox status, whereas the adaptive response may require GPAT1 activity itself PMID: 19193813

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  • 亞細(xì)胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    GPAT/DAPAT family
  • 組織特異性：
    Highest levels in liver, intermediate levels in muscle and kidney, and lowest levels in lung and brain.
  • 數(shù)據(jù)庫鏈接：