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  4. Recombinant Mouse H-2 class I histocompatibility antigen, D-37 alpha chain (H2-T23), partial

Recombinant Mouse H-2 class I histocompatibility antigen, D-37 alpha chain (H2-T23), partial

  • 中文名稱(chēng)：
    小鼠H2-T23重組蛋白
  • 貨號(hào)：
    CSB-YP361787MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    小鼠H2-T23重組蛋白
  • 貨號(hào)：
    CSB-EP361787MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    小鼠H2-T23重組蛋白
  • 貨號(hào)：
    CSB-EP361787MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    小鼠H2-T23重組蛋白
  • 貨號(hào)：
    CSB-BP361787MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    小鼠H2-T23重組蛋白
  • 貨號(hào)：
    CSB-MP361787MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    H2-T23
  • Uniprot No.：
  • 別名：
    H2-T23; H-2 class I histocompatibility antigen; D-37 alpha chain
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the presentation of foreign antigens to the immune system.
  • 基因功能參考文獻(xiàn)：
    1. In this study of C57BL mice, both H2-T23b and H2-T11b histocompatibility antigens are functional genes. PMID: 24958902
    2. Qa-1 antigens are sensors for defects in peptide processing in the endoplasmic reticulum. PMID: 22522492
    3. Qa-1(b) is critically involved in regulating IFN-gamma synthesis by NK cells in vivo through its interaction with CD94/NKG2A inhibitory receptors[Qa-1(b)] PMID: 17878358
    4. Qa-1 in complex with dominant peptide Qdm must be continuously replenished on target cells to inhibit recognition by CD94/NKG2A+ natural killer (NK) cells at physiological temperature, even when bound to peptide with an ideal binding sequence. PMID: 14734748
    5. varicellovirus UL49.5 protein is a universal TAP inhibitor that can be exploited for preclinical studies on CTL-based immune intervention[Qa-1b1] PMID: 17202325
    6. Qa-1-NKG2A interaction protected activated CD4+ T cells from lysis by a subset of NKG2A+ natural-killer cells PMID: 17509909
    7. Stable expression of Qa1 on the surface of mature dendritic cells (DC) contributes to the protection of DC from natural killer cell-mediated lysis. PMID: 18028286
    8. genetic disruption of the Qa-1-CD94/NKG2A interaction unleashes robust CD8 Treg cell activity that completely abolishes development of experimental allergic encephalomyelitis PMID: 19047627

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    MHC class I family
  • 數(shù)據(jù)庫(kù)鏈接：