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  4. Recombinant Mouse Hermansky-Pudlak syndrome 1 protein homolog (Hps1)

Recombinant Mouse Hermansky-Pudlak syndrome 1 protein homolog (Hps1)

  • 中文名稱：
    小鼠Hps1重組蛋白
  • 貨號(hào)：
    CSB-YP010711MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hps1重組蛋白
  • 貨號(hào)：
    CSB-EP010711MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hps1重組蛋白
  • 貨號(hào)：
    CSB-EP010711MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hps1重組蛋白
  • 貨號(hào)：
    CSB-BP010711MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hps1重組蛋白
  • 貨號(hào)：
    CSB-MP010711MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hps1
  • Uniprot No.：
  • 別名：
    Hps1; Ep; HpsHermansky-Pudlak syndrome 1 protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-704
  • 氨基酸序列
    MKCVLVATEG AEVLFYWTDE EFAESLRLKL QQSEDEEEEL PVLEDQLSTL LAPVIISSMT MLEKLSDTYT CFSTENDNHL YVLHLFGEYL FVAINGDHSE SEGDLRRKLC VLKYLFEVHF GLVTVDGQLI RKELRPPDLE ERARVWKHFQ RLLGTYSYLR DREQSFAVEA VERLIHPQLC EQSIETLERH VVQAINASPE RGGEEVLHAF LLVHCKLLAF YSGHGASTLR PADLLALILL VQDLQPSPGT TEEEEEEEDS DSPQRRPKSS QNIPVQQARS QSTSVPTRSS RETDTDSISL PEEYFTPAPS PGDQSSGSLV WLDGGTPPSD ALQMAEDTPE GLASHSPELP SPRRIFLDAN IKENYCPLVP HTMYCLPLWP GINMVLLTKS PSTPLALILY QLLDGFSLLE KKLKEGQEAG SALRSQPFVA DLRQKMDKFI KNRVGQEIQN TWLEFKSKAF SRSEPGSSWE LLQVCGKLKR QLCVIYRLSF LVTAPSRGGP HLPQHLQDRA QKLMKERLLD WKDFLLVKSR RNVTMVSYLE DFPGLVHFIY VDRTTGQMVA PSLSPNEKMS SELGKGPLAA FVKAKVWALV RLARRYLQKG CTTLLFQEGD FRCSYFLWFE NDMGYKLQMI EVPVLSDDSV PIGVLGGDYY RKLLRYYSKS HPSEPVRCYE LLTLHLSVIP TDLLVQQASQ LARRLGEASR VTLP
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.
  • 基因功能參考文獻(xiàn)：
    1. This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues. PMID: 25375251
    2. Our study indicates that Ap3b1 gene play distinct roles in melanin production and tyrosinase distribution compared with Hps1 gene. PMID: 25160823
    3. The mouse genes for HPS, pale ear and pearl, orthologous to the human HPS1 and HPS2 (ADTB3A) genes, copperate in production of platelet dense granules, melanosomes, and lysosomes. PMID: 11861280
    4. The coat-color phenotype of young homozygous double-mutant mice deficient in subunits of BLOC-3 (HPS1) and BLOC-1 (pallidin) was indistinguishable from that of BLOC-1 single mutants. PMID: 12847290
    5. Defects in the ep protein not only affect melanosome biogenesis, but also play a developmental role in determining interfollicular epidermal and dermal melanocyte function. PMID: 17068483

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  • 相關(guān)疾?。?/div>
    Defects in Hps1 are the cause of the pale ear (ep) mutant which exhibits hypopigmentation associated with defects of multiple cytoplasmic organelles, including melanosomes, lysosomes, and granular elements of platelets (PubMed:9256466).
  • 組織特異性：
    Expressed in all tissues examined with the possible exception of skeletal muscle. The highest expression was observed in lung, liver, kidney and spleen.
  • 數(shù)據(jù)庫鏈接：