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  4. Recombinant Mouse Homeobox protein Nkx-2.5 (Nkx2-5)

Recombinant Mouse Homeobox protein Nkx-2.5 (Nkx2-5)

  • 中文名稱：
    小鼠Nkx2-5重組蛋白
  • 貨號：
    CSB-YP015845MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nkx2-5重組蛋白
  • 貨號：
    CSB-EP015845MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nkx2-5重組蛋白
  • 貨號：
    CSB-EP015845MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nkx2-5重組蛋白
  • 貨號：
    CSB-BP015845MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nkx2-5重組蛋白
  • 貨號：
    CSB-MP015845MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nkx2-5
  • Uniprot No.：
  • 別名：
    Nkx2-5; Csx; Nkx-2.5; Nkx2eHomeobox protein Nkx-2.5; Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-318
  • 氨基酸序列
    MFPSPALTPT PFSVKDILNL EQQQRSLASG DLSARLEATL APASCMLAAF KPEAYSGPEA AASGLAELRA EMGPAPSPPK CSPAFPAAPT FYPGAYGDPD PAKDPRADKK ELCALQKAVE LDKAETDGAE RPRARRRRKP RVLFSQAQVY ELERRFKQQR YLSAPERDQL ASVLKLTSTQ VKIWFQNRRY KCKRQRQDQT LELLGPPPPP ARRIAVPVLV RDGKPCLGDP AAYAPAYGVG LNAYGYNAYP YPSYGGAACS PGYSCAAYPA APPAAQPPAA SANSNFVNFG VGDLNTVQSP GMPQGNSGVS TLHGIRAW
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression.
  • 基因功能參考文獻：
    1. Deletion of the Ahr gene in cardiomyocytes protects males from heart dysfunction due to NKX2.5 haploinsufficiency. PMID: 28973413
    2. Taken together, the authors identified a hemogenic angioblast cell lineage characterized by transient Nkx2.5 expression that contributes to hemogenic endothelium and endocardium, suggesting a novel role for Nkx2.5 in hemoangiogenic lineage specification and diversification. PMID: 28271994
    3. Nkx2-5 genetically interacts with Xrn2 because Nkx2-5(+/-)Xrn2(+/-), but neither Nkx2-5(+/-)nor Xrn2(+/-), newborns exhibited a defect in ventricular septum formation, suggesting that the association between Nkx2-5 and Xrn2 is essential for heart development. PMID: 27331609
    4. the present study demonstrates that mice with the R141C point mutation in the Nkx2.5 allele phenocopies humans with the NKX2.5 R142C point mutation. PMID: 28302382
    5. In the absence of NKX2-5 (or Smad-6), a severe form of rheumatic heart disease is observed. PMID: 26957275
    6. Study reports extensive and complex interdependent genomic occupancy of TBX5, NKX2-5, and the zinc finger TF GATA4 coordinately controlling cardiac gene expression, differentiation, and morphogenesis. PMID: 26875865
    7. The model proposed will help to elucidate the molecular basis for disease causing mutations in GATA4 and NKX2-5 and may be relevant to other members of the GATA and NK classes of transcription factors. PMID: 26642209
    8. MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby elevating SMA in a scar-like state. PMID: 26168347
    9. the Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node PMID: 26138475
    10. Findings implicate a novel, temporal-specific role of Mzf1 in embryonic heart development and show that Mzf1 bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation. PMID: 25436607
    11. A heterozygous Nkx2-5 missense mutation in the homeodomain demonstrates a high penetrance of diverse cardiac anomalies, similar to or more profound than those observed in human patients. PMID: 25028484
    12. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 transcriptional activity. PMID: 25725482
    13. Results show that NKX2-5 mRNA levels correlate with muscle histopathology in mice and humans and find that NKX2-5 levels modify disease phenotypes in mice with RNA toxicity. PMID: 25168381
    14. role for Nkx2-5 and Gata3 in the ontogeny of the smooth muscle gastric ligaments; gastric ligaments coexpress Gata3, Nkx2-5 and Sox9; germline loss of Gata3 or conditional deletion of Nkx2-5 abrogates Sox9 expression and impairs gastric ligament smooth muscle development PMID: 24970776
    15. Nkx2-5 has a role in regulating cardiac growth through modulation of Wnt signaling by R-spondin3 PMID: 25053429
    16. Data indicate that Nkx2-5, Tbx5, Gata4, or Myocd alone did not induce the de novo expression of cardiac marker proteins in 10T1/2 non-myoblastic cells. PMID: 23144723
    17. Nkx2-5 regulates the proliferation of both working and conduction myocytes in the atria in coordination with Notch activity. PMID: 24563458
    18. Findings indicate that Nkx2.5 in the mesoderm is essential while endodermal expression is dispensable for early heart formation in mammals. PMID: 24613616
    19. Nkx2-5 is independently required for the development of a pyloric outer longitudinal muscle fascicle, which is required for pyloric sphincter morphogenesis in mice. PMID: 24120474
    20. Hoxa10 cooperates with Nkx2-5 to regulate the timing of cardiac mesoderm differentiation. PMID: 23477547
    21. SIRT1 acts as a direct transcriptional target of Nkx2.5 that maintains cardiomyocyte homeostasis and survival. PMID: 23744058
    22. Nkx2.5 autoregulation is evolutionarily conserved in the second heart field PMID: 23165293
    23. In VEGF120/120 embryos, the Nkx2.5-positive mesenchymal population was disorganized with a short extension along the pulmonary cardiac outflow tract. PMID: 22826212
    24. excessive O-GlcNAcylation causes downregulation of Nkx2.5, which may be an underlying contributing factor for the development of diabetic cardiomyopathy PMID: 22719862
    25. Multiple logistic regression analysis for environmental variables revealed that maternal age is correlated with the risk of membranous and muscular VSD in Nkx2-5(+/-) but not wild-type animals. PMID: 22534315
    26. Genetic data suggest that a heterozygous missense mutation (P236H) in NKX2-5 is associated with isolated congenital asplenia (ICA). PMID: 22560297
    27. Over-expression of Nkx2.5 and/or cardiac alpha-actin inhibit the contraction ability of adipose tissue-derived stromal cells-derived cardiomyocytes. PMID: 21691712
    28. Overexpression of Csx/Nkx2.5 and GATA-4 enhances the efficacy of mesenchymal stem cell transplantation after myocardial infarction. PMID: 21828931
    29. Nkx2-5 and its responsive cis-regulatory DNA elements are essential for Atrial natriuretic factor expression selectively in the developing heart. PMID: 21930795
    30. Nkx2-5 is necessary for survival after the mid-embryonic stage for cardiac function and formation by regulating the expression of its downstream target genes. PMID: 21285290
    31. Data demonstrate that altered sumoylation status may underlie the development of congenital heart defects associated with Nkx2.5 mutants. PMID: 21677783
    32. results demonstrate that Shox2 downregulation of Nkx2.5 is essential for the proper development of the sinoatrial node and that Shox2 functions to shield the SAN from becoming working myocardium by acting upstream of Nkx2.5 PMID: 21640717
    33. Study identify that the homeobox gene Nkx2-5 is required for early ventral restriction of Slit3 and that the T-box transcription factor Tbx2 mediates repression of Slit3 in nonchamber myocardium. PMID: 20941780
    34. role for Pdgfralpha in transduction pathways that lead to repression of Nkx2.5 and WT1 during development of posterior heart field-derived cardiac structures. PMID: 20658695
    35. Stat3 is required for the differentiation of cardiomyocytes through direct transcriptional regulation of Tbx5, Nkx2.5, and GATA4 PMID: 20522556
    36. Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. PMID: 20212279
    37. induction of this gene is mediated by a SMAD consensus regulatory region PMID: 11944934
    38. heart-specific activity of enhancer requires evolutionary conserved Smad binding site PMID: 11944935
    39. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal thus suppressing myocardial chamber formation PMID: 12023302
    40. The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. PMID: 12122109
    41. NKX2.5 plays a role in mouse heart development PMID: 12141429
    42. Isoforms of PITX2 specifically regulate ANF expression and repression, synergistically with this transcription factor PMID: 12692125
    43. Nkx2.5 transactivates the Csm promoter, suggesting that Nkx2.5 is essential for embryonic Csm (cardiac-specific isoform of Mov10l1) expression PMID: 12754203
    44. Regulation of cardiac growth and development by SRF and its cofactors, including Nkx2.5. PMID: 12858529
    45. Role in heart development and disease. Review. PMID: 12858530
    46. effects of gene mutations on ventricular development PMID: 12858532
    47. cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5 PMID: 12858555
    48. LY294002 suppressed Csx protein expression, suggesting that PI3-kinase becomes activated and plays a pivotal role early in cardiomyocyte differentiation by modulating cardiac transcription factors. PMID: 14597408
    49. The expression of myocardin A and myocardin was markedly downregulated in Nkx2.5-null mouse hearts. PMID: 14645532
    50. early Nkx2-5 expression may be initiated by integration of GATA transcription factors with BMP signaling, through co-association with Smads factors PMID: 14662776

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 組織特異性：
    Predominantly in the adult and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach.
  • 數(shù)據(jù)庫鏈接：