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  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Hyaluronan and proteoglycan link protein 1 (Hapln1)

Recombinant Mouse Hyaluronan and proteoglycan link protein 1 (Hapln1)

  • 中文名稱：
    小鼠Hapln1重組蛋白
  • 貨號(hào)：
    CSB-EP010130MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hapln1重組蛋白
  • 貨號(hào)：
    CSB-EP010130MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hapln1重組蛋白
  • 貨號(hào)：
    CSB-BP010130MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:Hapln1 Synonyms:Crtl1
  • Uniprot No.：
  • 別名：
    Hapln1; Crtl1; Hyaluronan and proteoglycan link protein 1; Cartilage-linking protein 1; Cartilage-link protein; Proteoglycan link protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    10-356
  • 氨基酸序列
    I SVCWADHHLS DSYTPPDQDR VIHIQAENGP RLLVEAEQAK VFSHRGGNVT LPCKFYRDPT AFGSGIHKIR IKWTKLTSDY LREVDVFVSM GYHKKTYGGY QGRVFLKGGS DNDASLVITD LTLEDYGRYK CEVIEGLEDD TAVVALELQG VVFPYFPRLG RYNLNFHEAR QACLDQDAVI ASFDQLYDAW RGGLDWCNAG WLSDGSVQYP ITKPREPCGG QNTVPGVRNY GFWDKDKSRY DVFCFTSNFN GRFYYLIHPT KLTYDEAVQA CLNDGAQIAK VGQIFAAWKL LGYDRCDAGW LADGSVRYPI SRPRRRCSPT EAAVRFVGFP DKKHKLYGVY CFRAYN
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
  • 基因功能參考文獻(xiàn)：
    1. Aggrecan, link protein and TN-R were identified to be essential for the neuroprotective properties of the perineuronal net. PMID: 24625978
    2. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PMID: 23468913
    3. our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS PMID: 20566484
    4. there is a general and systemic function of link protein in the organization of extracellular matrix in a number of tissues, possibly interacting with other proteoglycans, such as versican, brevican, and neurocan PMID: 12732630
    5. Data suggest that the reported temporal co-expression of cartilage link protein and neurocan in developing brain implicates the possibility of a cooperative function of these molecules. PMID: 15062856
    6. reduced versican expression may contribute to a subset of the cardiac abnormalities observed in the Crtl1(-/-) mouse. PMID: 17822691

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  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    HAPLN family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接：