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  4. Recombinant Mouse Integrin alpha-6 (Itga6), partial

Recombinant Mouse Integrin alpha-6 (Itga6), partial

  • 中文名稱：
    小鼠Itga6重組蛋白
  • 貨號：
    CSB-YP720260MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Itga6重組蛋白
  • 貨號：
    CSB-EP720260MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Itga6重組蛋白
  • 貨號：
    CSB-EP720260MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Itga6重組蛋白
  • 貨號：
    CSB-BP720260MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Itga6重組蛋白
  • 貨號：
    CSB-MP720260MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Itga6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6; Alpha6p)]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
  • 基因功能參考文獻：
    1. alpha6 and beta1 integrins are induced in Schwann cells in the sciatic nerve after a crush injury, and the blocking of integrin activity by siRNA expression and by treatment with anti-integrin antibodies attenuates Schwann cell contact with cultured neurons and decreases neurite outgrowth. After nerve transection, the levels of alpha6 and beta1 integrins in the distal nerve stump are lower than corresponding nerve area... PMID: 29223350
    2. CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities. PMID: 29620414
    3. alpha6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. PMID: 27535718
    4. our data suggest that alpha6beta4 integrin upregulation is an inducible protective mechanism that stabilizes the blood-brain barrier during neuroinflammatory conditions. PMID: 29121970
    5. he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway. PMID: 27881869
    6. RFX1 transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development. PMID: 27228460
    7. pericyte alpha6beta1-integrin regulates tumour blood vessels by both controlling PDGFRbeta and basement membrane architecture. PMID: 28289267
    8. ITGA6 maintains structural integrity of the kidney collecting system. PMID: 28043890
    9. Integrin alpha 6 Expression on Microglia Surface and Motility on Laminin Is Up-regulated upon Adenosine Diphosphate Stimulation. PMID: 27655917
    10. Ahr ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression. PMID: 26996297
    11. interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 activates alpha6beta1/CD151 signaling which programs ESCs toward the endothelial cells lineage fate PMID: 25693840
    12. Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions. PMID: 24789282
    13. Immunohistological analysis of the tumors showed that Tie2-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2-expressing macrophages PMID: 25176420
    14. CD29 and CD49f have a critical role of in mediating cancer metastasis. PMID: 24317509
    15. NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels PMID: 24860089
    16. alpha6 integrin is an essential upstream regulator of the IGF-1R survival pathway that regulates the activity level of caspase-3 for it to signal differentiation initiation of lens epithelial cells. PMID: 24381169
    17. The expression of integrin-alpha6beta4 and laminin-5 (alpha3, beta3, gamma2) mRNAs was significantly higher on SA-treated c.p.Ti than on c.p.Ti and AO c.p.Ti disks after 3 days (P<0.05). PMID: 23415882
    18. Total ablation of alpha6 integrin altered cortical lamination, causing gaps in the basement membrane where neurons invade the cortical marginal zone. PMID: 23722246
    19. Integrin alpha1beta1 receptors play a role in platelet adhesion, activation and arterial thrombosis and could represent an alternative antithrombotic strategy with a potentially low bleeding risk. PMID: 23797810
    20. Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice. PMID: 22995187
    21. alpha6 plays a major role in both post-ischaemic angiogenesis and vasculogenesis. PMID: 22517984
    22. aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment PMID: 22464766
    23. The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells. PMID: 21799154
    24. Data show that a previously unrecognized subpopulation of mouse alveolar epithelial cells expressing the laminin receptor alpha6beta4, but little or no pro-surfactant C, is endowed with regenerative potential. PMID: 21701069
    25. Weak reactions for alpha6 integrin are also seen on surfaces of uterine natural killer cells on gestational days eight to ten only. PMID: 20201059
    26. cerebral hypoxia promotes first an endothelial response followed by astrocyte activation, proliferation, and reorganization of astrocyte end-feet, which correlates with increased expression of adhesion molecules alpha 6 beta 4 integrin and dystroglycan PMID: 20544851
    27. The alpha 6 integrin subunit is involved in branching morphogenesis of fetal mouse submandibular gland. PMID: 20224190
    28. tetraspanin CD151-alpha6beta1 integrin complex is fuctional unit during cellular morphogenesis PMID: 11809818
    29. PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane PMID: 12417630
    30. alpha6beta1 integrin-mediated adhesion to laminin-1 is selectively strengthened by CD151 PMID: 12805567
    31. Inhibition of the endogenous integrin alpha6 or beta1 subunit with locally injected antibodies disrupted the neuronal rostral migratory stream suggesting a role for integrins and laminins in adult neuroblast migration PMID: 14552869
    32. results suggest distinct roles for specific protein kinase C isoforms in alpha6beta4 integrin functional regulation during the early stages of skin differentiation PMID: 14715240
    33. alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met PMID: 15161909
    34. This cytokine-specific role of alpha6 integrin was associated with enhanced cell-surface expression of alpha6beta1 on transmigrated neutrophils (as compared with blood cells) in response to IL-1beta but not TNF-alpha. PMID: 15539457
    35. integrin alpha6beta4 is not required for postnatal epidermal differentiation, proliferation and survival, provided that cell adhesion is not compromised PMID: 15731010
    36. PECAM-1, alpha6 integrins and neutrophil elastase work together to mediate neutrophil transmigration PMID: 15840647
    37. Changes in Itga6 expression during adipocyte differentiation demonstrate its role in connecting morphogenesis with signal processes leading to terminal differentiation. PMID: 16154099
    38. alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase-Cdc42/Rac pathways may play a role in determining the size and shape of tooth germ PMID: 16365040
    39. observations suggest a role for alpha 6 integrin in neural migration during olfactory development, likely secondary to organization of the radial glial scaffold PMID: 16374711
    40. PMP22 is a binding partner in the integrin alpha6beta4/laminin complex. PMID: 16436605
    41. The spatiotemporal modulation of alpha6 expression suggests changing roles for this integrin during the early development of inner ear innervation. PMID: 17436285
    42. Absence of integrin alpha 6 impairs keratinocyte adhesion and alters expression of genes involved in signal transduction and cell differentiation. PMID: 17474077
    43. alpha6beta4 can either mediate an adhesion-independent tumor-suppressive effect or act as a tumor promotor PMID: 17699601
    44. Oxygen-glucose deprivation produced a further significant increase in subunit beta1 expression by both cell types, but a clear decrease in both alpha1 and alpha 6 subunits by murine astrocytes. PMID: 18032737
    45. These data indicate that, similar to its role in skin, alpha6beta4 integrin confers stability to myelin in peripheral nerves. PMID: 18579745
    46. PODXL(hi)/CD49f(hi) MSCs were less prone to produce lethal pulmonary emboli PMID: 18818395
    47. Blockade of the alpha6-integrin enhanced bone marrow (BM) homing of human and nonhuman primate BM-derived hematopoietic stem/progenitor cells. PMID: 18842099
    48. Combinatorial selection based on phage display technology revealed a previously unrecognized complex between the soluble protein netrin-4 and laminin gamma1 subunit that activates an alpha6beta1 integrin-mediated signaling pathway in neural stem cells PMID: 19193855
    49. novel model for the disassembly of hemidesmosomes where both binding of calmodulin to plectin 1a and phosphorylation of integrin beta4 by protein kinases, are required for disruption of the integrin alpha6beta4-plectin complex PMID: 19419971
    50. these results highlight for the first time the considerable role of the integrin alpha6beta1 in glioma progression. PMID: 19574430

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
  • 蛋白家族：
    Integrin alpha chain family
  • 組織特異性：
    [Processed integrin alpha-6]: Expressed at low levels in normal skin tissue with elevated levels in skin tumors.
  • 數(shù)據(jù)庫鏈接：