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  4. Recombinant Mouse Na (+)/H (+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1)

Recombinant Mouse Na (+)/H (+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1)

  • 中文名稱：
    小鼠Slc9a3r1重組蛋白
  • 貨號：
    CSB-YP021733MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Slc9a3r1重組蛋白
  • 貨號：
    CSB-EP021733MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Slc9a3r1重組蛋白
  • 貨號：
    CSB-EP021733MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Slc9a3r1重組蛋白
  • 貨號：
    CSB-BP021733MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Slc9a3r1重組蛋白
  • 貨號：
    CSB-MP021733MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Slc9a3r1; Nherf; Nherf1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; NHERF-1; Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-355
  • 氨基酸序列
    SADAAAGEP LPRLCCLEKG PNGYGFHLHG EKGKVGQFIR LVEPGSPAEK SGLLAGDRLV EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDERLK KLGVSIREEL LRPQEKSEQA EPPAAADTHE AGDQNEAEKS HLRELRPRLC TMKKGPNGYG FNLHSDKSKP GQFIRAVDPD SPAEASGLRA QDRIVEVNGV CMEGKQHGDV VSAIKGGGDE AKLLVVDKET DEFFKKCKVI PSQEHLDGPL PEPFSNGEIQ KESSREALVE PASESPRPAL ARSASSDTSE ELNSQDSPKR QVSTEPSSTS SSSSDPILDL NISLAVAKER AHQKRSSKRA PQMDWSKKNE LFSNL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
  • 基因功能參考文獻(xiàn)：
    1. our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes. PMID: 27540115
    2. The results provide evidence that NHERF1 mediates K(+) current activity through acceleration of the surface expression of ROMK1 K(+) channels in M-1 cells. PMID: 28533091
    3. The NHERF1 is as putative molecular organizer of signal transduction in vomeronasal neurons. PMID: 27655939
    4. we show here that NHERF1 loss from the PM is oncogenic in vivo through its influence on Wnt-APC-beta-catenin and Hippo-YAP pathways. PMID: 27566107
    5. NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3 PMID: 27279487
    6. These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes. PMID: 17975671
    7. Results strongly support an important role for NHERF1 in the regulation of Planar Cell Polarity signaling and the development of functional motile cilia. PMID: 27055101
    8. the activation of PTEN and NHERF-1 may impede the evolution of macrophages beyond the M1 into M2 phenotype in tumor microenvironment. PMID: 25756512
    9. Data show that interaction of the inducible nitric oxide synthase (iNOS) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis. PMID: 26183564
    10. The expression of EBP50 was not significantly different in the pseudopregnant uterus and decreased in the uteri subjected to activation of delayed implantation. PMID: 23208378
    11. NHERF1 is differentially distributed to rafts and non-raft brush border membrane fractions of NHE3. PMID: 24297041
    12. EBP50 expression is induced by inflammatory stimuli and potentiates NF-kappaB activation and inflammation in primary macrophages and VSMC. PMID: 24196963
    13. siRNA knockdown of PEX7 reduced iNOS colocalization with the peroxisomal protein PMP70. Proteomic studies using MALDI-MS identified iNOS association with the 50-kD ezrin binding PDZ protein (EBP50). PMID: 23474170
    14. EBP50 promotes focal adhesion turnover and vascular smooth muscle cells migration. PMID: 22974528
    15. NHERF1 regulates PTH that differentially affects Na-dependent Pi transport at distinct stages of osteoblast proliferation and maturation PMID: 23046970
    16. NHERF1 is required for normal osteoblast differentiation and matrix synthesis. In its absence, compensatory mechanisms maintain bone mass, but bone strength is reduced. PMID: 23109343
    17. NHERF1 engages prolactin receptor in structural complexes that maintain the polarity and directional signaling via STAT5 activation, through expression upregulation and strategic localization at the basal membrane of alveolar cells. PMID: 22992649
    18. EBP50 is critical for neointima formation and induces vascular smooth muscle cell proliferation by decreasing S-phase kinase protein2 stability, thereby accelerating the degradation of the cell cycle inhibitor p21(cip1). PMID: 22034511
    19. Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. PMID: 21908609
    20. The NHERF1-binding domains of cystic fibrosis transmembrane conductance regulator and Csk-binding protein were also found to act as transferable retention signals. (NHERF1 protein) PMID: 21444686
    21. The differential affinity of the Na/P(i) transporters for NHERF-1 and PDZK1 proteins could partially explain their differential regulation and/or stability in the apical membrane. PMID: 21388960
    22. NHERF-1 mouse may represent a defect in the proximal tubule resulting in reduced calcium reabsorption like human idiopathic calcium oxalate stone formers PMID: 21063698
    23. Data shsow that the changes in the jejunal BBMV proteome of NHERF1 null mice are consistent with a more complex role of NHERF1 than just forming signaling complexes and anchoring proteins to the apical membrane. PMID: 20736413
    24. The phosphorylation of Thr(95) facilitates the phosphorylation of Ser(77). This, in turn, results in the dissociation of NHERF-1 from Npt2a and a decrease in phosphate transport in renal proximal tubule cells. PMID: 20571032
    25. NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow PMID: 20404332
    26. NHERF-1 plays a key role in dopamine signaling and is also a downstream target of D1-like receptors in the mouse kidney. PMID: 20200151
    27. NHERF1 overexpression in CFBE41o- rescues CFTR-dependent chloride secretion by forming the multiprotein complex RhoA-ROCK-ezrin-actin that tethers F508del CFTR to the cytoskeleton stabilizing it on the apical membrane. PMID: 19889841
    28. the involvement of NHERF1 and TAZ in mediating the effects of the ephrin B1 ligand on osteoblast function was studied. PMID: 19995908
    29. data suggested that NHERF-1 played a unique role in the apical targeting and/or trafficking of Npt2 in the mammalian kidney, a function not shared by NHERF-2 or other renal PDZ proteins PMID: 12169661
    30. NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in renal apical membranes. PMID: 12586353
    31. NHERF-1 has a role in parathyroid hormone regulation of Na-K ATPase in epithelial cells PMID: 12819230
    32. full renal adaptation to a low-phosphate diet requires NHERF-1, which serves to increase brush border expression of Npt2. PMID: 12952857
    33. PDZK1 and NHERF-1 establish an extended network beneath the apical membrane to which membrane proteins and regulatory components are anchored. PMID: 14531806
    34. NHE1 null mutation does alter the expression of other membrane transporters at both protein and mRNA levels. PMID: 14596847
    35. SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant PMID: 15466885
    36. overall effect of NHERF is to enhance the fraction of receptors present at the cell surface PMID: 15469991
    37. The structural defects found in the EBP50(-/-) intestinal microvilli were reminiscent of those described in ezrin(-/-) mice PMID: 15591354
    38. in the cystic fibrosis cell lines, CFBE41o- and CFT1-C2, targeted NHERF1 overexpression induced the redistribution of CFTR from the cytoplasm to the plasma membrane and rescues CFTR activity PMID: 16203733
    39. studies indicate defects in the renal tubule transport of phosphate, calcium, and uric acid in NHERF-1(-/-) male and female mice that could account for the increased deposition of calcium in the papilla of null mice PMID: 16249272
    40. NHE1 activity disrupts sodium and calcium homeostasis and contributes to ischemic neuronal damage PMID: 16339021
    41. Using both genetic and biochemical approaches, the authors have identified the Na(+)/H(+) exchanger regulatory factor-1 (NHERF-1) as a selective ligand for podocalyxin and endoglycan but not for the closely related CD34. PMID: 16410385
    42. analysis of NHERF recognition by ERM proteins PMID: 16615918
    43. specific role of NHERF-1 on regulated Npt2a trafficking and sodium-dependent phosphate transport. PMID: 16705152
    44. NHERF1 emerges as a cofactor essential for the integrity of epithelial tissues by maintaining the proper localization and complex assembly of beta-catenin PMID: 17325659
    45. Carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70. PMID: 17390218
    46. NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters. PMID: 17409311
    47. in proximal tubule, NHERF1 is required for all cAMP inhibition of NHE3, which occurs through both EPAC-dependent and PKA-dependent mechanisms; in contrast, cAMP inhibits ileal NHE3 only by a PKA-dependent pathway, which is independent of NHERF1 and EPAC PMID: 17580307
    48. serine 77 phosphorylation plays a key role in modulating NHERF-1 association with plasma membrane targets PMID: 17895247
    49. NHERF-1 but not NHERF-2 in native intestinal epithelium is involved in the formation of CFTR-containing functional complexes that serve to position CFTR in the crypt apical membrane and to optimize its function as a cAMP- and cGMP-regulated anion channel PMID: 17947234
    50. biologic activity of NHERF1 in mammary gland is related to PTEN signaling. PMID: 18190691

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  • 亞細(xì)胞定位：
    Cytoplasm. Apical cell membrane. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Endomembrane system; Peripheral membrane protein.
  • 組織特異性：
    Expressed in spermatogenic cells.
  • 數(shù)據(jù)庫鏈接：