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  4. Recombinant Mouse PR domain zinc finger protein 1 (Prdm1), partial

Recombinant Mouse PR domain zinc finger protein 1 (Prdm1), partial

  • 中文名稱：
    小鼠Prdm1重組蛋白
  • 貨號(hào)：
    CSB-YP720159MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Prdm1重組蛋白
  • 貨號(hào)：
    CSB-EP720159MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Prdm1重組蛋白
  • 貨號(hào)：
    CSB-EP720159MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Prdm1重組蛋白
  • 貨號(hào)：
    CSB-BP720159MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Prdm1重組蛋白
  • 貨號(hào)：
    CSB-MP720159MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Prdm1
  • Uniprot No.：
  • 別名：
    Prdm1; Blimp1; PR domain zinc finger protein 1; EC 2.1.1.-; B lymphocyte-induced maturation protein 1; Blimp-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
  • 基因功能參考文獻(xiàn)：
    1. Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes. PMID: 30257949
    2. B lymphocyte-induced maturation protein 1 (Blimp1) expression defines a mammary stem cell subpopulation with unique functional characteristics. PMID: 29158490
    3. Blimp1-dependent transcripts are enriched in spiral artery trophoblast giant cells. PMID: 27108815
    4. Moreover, the authors showed that Sirt6, induced by RANKL-dependent NFATc1 expression, forms a complex with B lymphocyte-induced maturation protein-1 (Blimp1) to negatively regulate expression of anti-osteoclastogenic gene such as Mafb. PMID: 27189179
    5. Posterior PRDM1 contributes more broadly to the developing fetal-maternal connection than previously recognized, and PRDM1 and STELLA, while overlapping in putative primordial germ cells, also co-localize in several other tissues PMID: 27696611
    6. Blimp1 deficiency resulted in reduced suppressive ability of Tfr cells. This study identifies that Tfr cells are potent suppressors of immunity and are controlled by Blimp1. PMID: 28833081
    7. Data show that TLR4-mediated up-regulation of Blimp-1 led to the down-regulation of NLRP12 expression in dextran sulfate sodium (DSS)-induced colitis. PMID: 27105524
    8. Results established a molecular mechanism of TNF-a-induced osteoclasts differentiation, and provided insights into the potential contribution of Blimp1 in the regulation of osteoclastogenesis by TNF-a. PMID: 27505147
    9. results show that the intersection of three or more transcription factors is required to correctly regulate the spatial and temporal features of Blimp1 enhancer expression PMID: 28829770
    10. findings show that Prdm1 acts independently of Aire, a crucial transcription factor implicated in medullary thymic epithelial cells function; data highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function PMID: 28701508
    11. role in natural antibody production by B-1 and B-1-derived plasma cells PMID: 28698287
    12. Prdm1 repressed expression of the gene encoding cathepsin S (Ctss). Prdm1 deficiency in dendritic cells led to loss of appropriate regulation of Ctss expression in female mice and thereby modulated antigen presentation and the follicular helper T cell repertoire to contribute to autoimmunity in lupus. PMID: 28692065
    13. Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis. PMID: 27190036
    14. Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1). PMID: 27941793
    15. role of Blimp-1 as a critical regulator of CD4 dysfunction and links it to the CD8 T cell dysfunctionality observed in infected mice. PMID: 27481131
    16. Contextual ablation of BLIMP-1 and p53 led to development of IgM-positive B-cell lymphoma with an aggressive phenotype, supported by c-Myc up-regulation, and accumulation of somatic mutations, as demonstrated by whole exome sequencing. PMID: 28474779
    17. this study shows that IL-10 production during B-cell development is strongly correlated with the expression level of Prdm1 PMID: 28012163
    18. The escape of a fraction of Primordial germ cells from the Prdm1 deletion was sufficient to recover fairly normal germ cell pools, both in male and female adults PMID: 26586842
    19. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet. PMID: 26950239
    20. Reduction of HDAC3 or NCoR1 expression by RNA interference in B cells resulted in an increased Prdm1 mRNA expression. PMID: 26786103
    21. TCF1 is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 and Blimp1. PMID: 26365183
    22. Blimp1 was dispensable for survival of plasma cells. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response. PMID: 26779600
    23. Blimp1 promoted the migration and adhesion of plasmablasts, silenced B cell-specific gene expression, antigen presentation and class-switch recombination in plasmablasts, and induced immunoglobulin gene transcription and secretion. PMID: 26779602
    24. In a genetically engineered mouse model of soft tissue sarcoma that loss of GCN2 has no effect on tumor growth or animal survival. PMID: 26123823
    25. Blimp-1 likely has distinct gene-regulating activities depending on the inflammatory or anti-inflammatory enhancer landscape created by a multi-factorial transcriptional complex PMID: 26750311
    26. From these results, we defined the distinct functions of Blimp-1 and Akt and provided mechanistic insights into the acquisition of pluripotency in Primordial germ cells. PMID: 26050930
    27. LPS-PG completely abrogates RANKL-induced gene expression of B lymphocyte-induced maturation protein-1 (Blimp1), a global transcriptional repressor of anti-osteoclastogenic genes encoding Bcl6, IRF8, and MafB PMID: 26483549
    28. these results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations. PMID: 27102484
    29. identify Blimp-1-dependent IL-10 produced by Tr1 cells as a key regulator of TNF-mediated pathology PMID: 26765224
    30. in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine. PMID: 26158850
    31. Inhibition of Blimp1 reduces the production of autoantibody and alleviates symptoms of systemic lupus erythematosus. PMID: 25347333
    32. Expression of Blimp-1 in dendritic cells modulates the innate inflammatory response in dextran sodium sulfate-induced colitis PMID: 25826676
    33. Data show that PRD1-BF1/Blimp expression in tumor vasculature predicts sensitivity to Oncolytic Vaccinia Virus infection. PMID: 26212250
    34. Loss of Blimp1 perturbs differentiation in all epidermal lineages. PMID: 25358790
    35. results suggest that IL-33-ST2 interactions down-regulate both RANKL-induced NFATc1 activation and osteoclast differentiation via the regulation of Blimp-1 and IRF-8 expressio PMID: 25795135
    36. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. PMID: 24821700
    37. p53-mediated aging of the skin involves not only thinning through the loss of Blimp1+ subdermal fat. PMID: 24675459
    38. study identifies the SWI/SNF complex as a key mediator in GC reactions by modulating Bcl-6-dependent Blimp-1 repression PMID: 25646472
    39. Data indicate that E3 ubiquitin-protein ligase Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1) to promote MHC-II antigen expression. PMID: 25366967
    40. Truncated OSTM1 significantly inhibited the expression of osteoclast marker genes through the down-regulation of the BLIMP1-NFATc1 axis. PMID: 25359771
    41. Restimulation of Th1 cells from LCMV-infections promoted BLIMP-1 and subsequent IL-10 expression, suggesting that constant antigen exposure likely induces the BLIMP-1/IL-10 pathway during chronic viral infection. PMID: 25003188
    42. Blimp-1 expression is not necessary for the generation of functional memory CD8+ T cells. Blimp-1 deficiency affects effector differentiation and function in the absence of inflammation. PMID: 25015830
    43. IL-10 production from Th1 cells was strictly dependent on Blimp-1 but was further enhanced by the synergistic function of c-Maf, a transcriptional regulator of IL-10 induced by multiple factors, such as the Notch pathway. PMID: 25073792
    44. deregulated Syk activity by itself is not sufficient for the transformation of B cells, as downstream effectors, such as Blimp-1, limit the survival and expansion of the activated B cell PMID: 23955076
    45. It was concluded that BLIMP-1 suppresses autoimmune encephalomyelitis via downregulating Th1 and Th17 cells and impairing Treg cells. PMID: 24568746
    46. Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection. PMID: 24590765
    47. these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8. PMID: 24477914
    48. Blimp1 likely forms a cross-repressive network with pro-bipolar factors such that the winner of this interaction stabilizes the photoreceptor or bipolar state, respectively PMID: 24125957
    49. OX40 stimulation of virus-specific CD4 T cells promoted expression of the transcriptional repressor Blimp-1 and diverted the majority of cells away from follicular Th cell differentiation. PMID: 24101548
    50. Data indicate that B lymphocyte induced maturation protein 1 (Blimp1) was strongly expressed in the kidneys, lymph nodes and spleen of MRL/lpr lupus mice. PMID: 23911415

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 組織特異性：
    Expressed in innate lymphocytes, including tissue-resident conventional natural killer (cNK) cells in liver. Expressed also weakly in tissue-resident natural killer (trNK) and natural killer T (NKT) cells in liver. Isoform 1 is detected in bone marrow, sp
  • 數(shù)據(jù)庫(kù)鏈接：