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  4. Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Pik3cg), partial

Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Pik3cg), partial

  • 中文名稱：
    小鼠Pik3cg重組蛋白
  • 貨號：
    CSB-YP878048MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pik3cg重組蛋白
  • 貨號：
    CSB-EP878048MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pik3cg重組蛋白
  • 貨號：
    CSB-EP878048MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pik3cg重組蛋白
  • 貨號：
    CSB-BP878048MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pik3cg重組蛋白
  • 貨號：
    CSB-MP878048MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pik3cg; Pi3kg1; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; Serine/threonine protein kinase PIK3CG; EC 2.7.11.1; p120-PI3K
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
  • 基因功能參考文獻(xiàn)：
    1. Deficient mice in the canonical PI3Kgamma signaling (Pik3cg-/-) are more susceptible to T. cruzi infection. The canonical PI3Kgamma signaling in myeloid cells restricts heart parasitism and avoids heart damage and death of mice. PMID: 29666415
    2. the beneficial action of PI3Kgamma ablation in obesity-driven glucose intolerance is largely a result of its leptin-dependent effects on adiposity and, to a lesser extent, the promotion of adipose tissue neutrophil recruitment and M1 polarization of gene expression PMID: 28904022
    3. As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics. PMID: 28963139
    4. PI3K( PI3Kgamma(null) versus PI3Kgamma(WT) mice) inhibition slows tumor growth, enhances antitumor immunity, and heightens susceptibility to immune checkpoint inhibitors. We propose that combining PI3K inhibition with anti-PD1 may be a viable therapeutic approach for triple-negative breast cancer PMID: 28003307
    5. PI3Kg ablation protects mice from obesity, inflammation, and insulin resistance caused by high-fat diet feeding. PMID: 28720716
    6. The results showed that PI3K-gamma is likely a crucial element in sepsis-induced myocardial dysfunction (SIMD) by regulating the PI3K/Akt pathway, and become a new marker of myocardial injury. Inhibition of PI3K-gamma might be a potential therapeutic target in SIMD. PMID: 28458167
    7. Phosphatidylinositol-3-kinases (PI3K) gamma and delta are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kgamma or PI3Kdelta deficiency prolongs graft survival, but selective inhibition of PI3Kgamma or PI3Kdelta reveals alternative transplant survival outcomes post CTLA4-Ig treatment. PMID: 29038423
    8. PI3Kgamma kinase activity-independent control of cAMP phosphodiesterase as a crucial mediator of microglial cAMP regulation, MMP-9 expression, and phagocytic activity following focal brain ischemia/recirculation. PMID: 26452362
    9. We report here that PI3Kgamma regulates macrophage transcriptional programming, leading to T-cell suppression, desmoplasia, and metastasis in pancreas adenocarcinoma. PMID: 27179037
    10. a STOP mutation in the GM-CSFRalpha chain, leading to a complete and specific deficiency in GM-CSF signaling, is reported. PMID: 27468760
    11. increased levels of eosinophils and IgE in p110gamma/delta-/- mice do not abolish the protective effect of p110gamma/delta-deficiency against OVAlbumin-induced allergic airway inflammation. PMID: 27442134
    12. The Effector PI3Kgamma Is Required for Toll-like Receptors-induced Akt/mTOR Signaling and Regulation of Cytokine Responses. PMID: 28130450
    13. macrophage PI 3-kinase gamma controls a critical switch between immune stimulation and suppression during inflammation and cancer; therapeutic targeting of intracellular signalling pathways that regulate the switch between macrophage polarization states can control immune suppression in cancer and other disorders PMID: 27642729
    14. Accumulation of PtdIns(3,4,5)P3, but not PtdIns(3,4)P2,in neutrophils were dependent on PI3Kgamma activity. PMID: 26596865
    15. identify PI3Kgamma as a novel key host protective factor in influenza virus infection and shed light on an unappreciated layer of complexity concerning the role of PI3K signaling in this context PMID: 27030971
    16. Pik3cg(-/-) mice had persistent lung inflammation induced by sepsis and increased in vascular permeability. Restoration of p110gamma in pulmonary endothelial cellsrestored endothelial regeneration and normalized the defective vascular repair program. PMID: 26839042
    17. Results found that the absence of PI3Kgamma significantly delayed mortality and reduced clinical signs and histopathological brain changes associated with Plasmodium berghei infection. PMID: 25775137
    18. The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB signaling exerted by a kinase-independent PI3Kgamma-PDE4D interaction in the noradrenergic neurons of the locus coeruleus. PMID: 25882071
    19. platelet PI3Kgamma contributes to platelet-mediated vascular inflammation and carotid intima-media thickening after flow severely reduced. Platelet PI3Kgamma may be a new target in the treatment of vascular diseases. PMID: 26053836
    20. The Ras-PI3Kgamma-Akt-mTOR signaling axis acts downstream of FLT3L signaling and is required for development of lung CD103(+)and CD11b(+) dendritic cells. PI3Kgamma is an essential organ-specific regulator of lung dendritic cell development PMID: 26453378
    21. The regulatory subunits of PI3Kgamma control distinct neutrophil responses. PMID: 25605974
    22. p110[gamma] but not p110[delta]-specific inhibitor ameliorates renal ischemia-reperfusion injury by reducing necrosis and immune cell migration PMID: 26431158
    23. The interaction between PI3Kgamma and CNGA1 does not appear to play a role in regulation of CNG channel activity, but PI3Kgamma uses CNGA1 as an anchoring module to achieve close proximity to its substrate to generate D3-phosphoinositides PMID: 25644171
    24. puerarin prevents Abeta-induced microglial apoptosis via the activation of PI3K/Akt signaling pathway PMID: 25173404
    25. Combined inhibition of PI3Kbeta and PI3Kgamma reduces fat mass by enhancing alpha-MSH-dependent sympathetic drive, thus perhaps a promising treatment for obesity. PMID: 25406378
    26. The lack of PI3Kgamma revealed a deleterious effect in an animal model of convulsions induced by pilocarpine, suggesting that this enzyme may play a protective role in seizures PMID: 25749189
    27. Kinase-independent control of cAMP phosphodiesterase activity by PI3Kgamma is a crucial mediator of microglial cell activation, MMP expression and subsequent BBB deterioration. PMID: 25033932
    28. These results, together with the previous knockout study, suggest that a critical level of PI3Kgamma in the hippocampus is required for successful induction of long-term depression and normal learning. PMID: 25373491
    29. phosphatidylinositol 3-kinase gamma has a role in insulin secretion induced by glucose-dependent insulinotropic polypeptide PMID: 25288806
    30. The data indicate that PI3Kgamma has a critical role in cAMP-mediated inflammatory hypernociception and analgesic signalling via mu-opioid receptors and PI3K/Akt in neuronal cells. PMID: 24654606
    31. PI3Kgamma-deficient mice and mice expressing catalytically inactive PI3Kgamma (PI3Kgamma KD) showed reduced arterial occlusion and accumulation of monocytes and T cells around sites of vascular lesion. PMID: 25073791
    32. PI3Kgamma kinase activity is required for optimal T-cell activation and differentiation, as well as for mounting an efficient T cell-mediated immune response. PMID: 24030559
    33. PKCbeta-mediated p110gamma phosphorylation disconnects PI3Kgamma from its canonical inputs from trimeric G proteins. PMID: 23824069
    34. IgE-mediated mast cell accumulation was strictly PI3Kgamma dependent in IGE challenged skin. PI3Kgamma controls multiple steps in the recruitment process. PMID: 23683463
    35. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PMID: 23565202
    36. findings indicate PI3Kgamma-dependent suppression of cAMP signaling as a critical regulatory element of microglial phagocytosis. PMID: 23276671
    37. Loss of PI3Kg is protective in the early phases of hapten-induced colitis, but loss of this signaling protein hinders the resolution of inflammation in the colon. PMID: 23282580
    38. The PI3Kgamma regulates the activity of RalA, which is one of the molecular mechanisms inducing N-methyl-D-aspartate receptor-dependent long-term depression. PMID: 23433113
    39. kinase-independent function of PI3Kgamma could directly inhibit GSK-3 function by preventing the PP2A-PPMT-1 interaction and that this inhibition of GSK-3 was independent of Akt. PMID: 23354687
    40. Campylobacter jejuni-induced PI3K-gamma signaling mediates neutrophil recruitment and intestinal inflammation in interleukin (IL)10-deficient mice. PMID: 23180818
    41. PI3Kgamma promotes development of experimental autoimmune encephalomyelitis. PMID: 23028778
    42. PI3-kinase p110gamma mediates initial podocyte injury and proteinuria, both of which precede TGF-beta-mediated glomerular scarring in adriamycin nephropathy. PMID: 22534961
    43. Mice lacking functional PI3Kdelta or PI3Kgamma are largely protected from experimentally induced psoriatic dermatitis and correlate with reduced interleukin (IL)-17 levels in lesions, serum, and draining lymph nodes. PMID: 23024273
    44. Intranasal administration of a broad-spectrum PI3K inhibitor or a PI3Kgamma-specific inhibitor 1 h before AHR assessment attenuated IL-13 effects. PMID: 22543031
    45. the knockdown of p110gamma in murine epithelial carcinoma 4T1.2 cells inhibited primary tumor growth and spontaneous metastasis, as well as lung colonization PMID: 21996737
    46. p110gamma PI3K signaling regulates BCL6 expression. PMID: 22422878
    47. Activation of peripheral KORs directly blocks inflammatory hyperalgesia through stimulation of the nNOS/NO signaling pathway which is probably stimulated by PI3Kgamma/AKT signaling. PMID: 22316281
    48. results show that GM-CSF-differentiated murine macrophages become foam cells by fluid-phase pinocytosis of LDL and identify PI3Kgamma as contributing to this process. PMID: 22058424
    49. PI3Kgamma plays a critical role in pathogenesis of chronic cutaneous leishmaniasis caused by L. mexicana. PMID: 22232690
    50. Increased acidification of CpG-containing endosomes in p110gamma(-/-) cells enforces endosomal escape of CpG, which results in increased association of CpG with DNA-PKcs to up-regulate IL-10 production in macrophages. PMID: 22053215

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    PI3/PI4-kinase family
  • 數(shù)據(jù)庫鏈接：