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  4. Recombinant Mouse Phospholipase A2, membrane associated (Pla2g2a)

Recombinant Mouse Phospholipase A2, membrane associated (Pla2g2a)

  • 中文名稱：
    小鼠Pla2g2a重組蛋白
  • 貨號(hào)：
    CSB-YP018091MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pla2g2a重組蛋白
  • 貨號(hào)：
    CSB-EP018091MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pla2g2a重組蛋白
  • 貨號(hào)：
    CSB-EP018091MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pla2g2a重組蛋白
  • 貨號(hào)：
    CSB-BP018091MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pla2g2a重組蛋白
  • 貨號(hào)：
    CSB-MP018091MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pla2g2a; Phospholipase A2; membrane associated; EC 3.1.1.4; Enhancing factor; EF; GIIC sPLA2; Group IIA phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2A
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    22-146
  • 氨基酸序列
    NIAQFGEMI RLKTGKRAEL SYAFYGCHCG LGGKGSPKDA TDRCCVTHDC CYKSLEKSGC GTKLLKYKYS HQGGQITCSA NQNSCQKRLC QCDKAAAECF ARNKKTYSLK YQFYPNMFCK GKKPKC
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response. Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. PLA2 promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection. PMID: 28808157
    2. secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer. PMID: 27292189
    3. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase. PMID: 27060751
    4. Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases. PMID: 26659873
    5. Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta) and Group X Secreted Phospholipase A2 (sPLA2). PMID: 26655718
    6. Data show that the coordinated action of phospholipase A2 IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO) promotes inflammatory arthritis. PMID: 26106157
    7. Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains. PMID: 24913681
    8. hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation PMID: 25082876
    9. Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation. PMID: 24998360
    10. two of these isoforms, sPLA2 IIA and sPLA2 IIF, localize to the upper stratum granulosum and increase in response to experimental barrier perturbation. PMID: 24269828
    11. Investigation into the role of phosphatidylserine in modifying the susceptibility of lymphocytes to secretory phospholipase A(2) using cells deficient in the expression of scramblase. PMID: 22266334
    12. Treated mice exhibited upregulated sPLA2-IIa and cytokine gene transcription. PMID: 21519031
    13. results suggest that the tumor cell iPLAbeta-lysophosphatidic acid axis may represent a novel target for prostate cancer PMID: 20812222
    14. sPLA(2) may play a role in the development of the histologic changes produced by gastroduodenal reflux in esophageal mucosa. PMID: 20095996
    15. Secretory PLA2 plays a novel anti-inflammatory role in rheumatoid arthritis. PMID: 20432503
    16. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals PMID: 20086008
    17. Endogenous mouse sPLA(2) gene does not significantly affect HDL or atherosclerosis in mice. PMID: 12054745
    18. cPLA(2)alpha plays a discrete role in the collagen-stimulated production of TX and its inhibition has a therapeutic potential against thromboembolism, with potentially limited bleeding expected. PMID: 12163563
    19. Expression of enhancing factor/phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis. PMID: 12673199
    20. the effect of group IIa and V PLA2s on H2O2-induced AA release is dependent upon the presence of cPLA2alpha and the activation of PKC and ERK1/2. Group IIa and V PLA2s are regulatory and cPLA2alpha is responsible for AA release. PMID: 12676927
    21. Hydrolysis of surfactant phosphatidylglycerol by group IIA secreted phospholipase A2 in vivo leads to an impairment of surfactant function in a mouse model of acute lung injury. PMID: 12847272
    22. Group V sPLA2 may play an important role in promoting atherosclerotic lesion development by modifying LDL particles in the arterial wall, thereby enhancing particle aggregation, retention, and macrophage uptake. PMID: 14962950
    23. experimental Plasmodium berghei infections of cytosolic PLA2 and PLA2IIA-deficient CL57B/6 mice resulted in cerebral malaria and rapid death; findings are expected to help clarify the involvement of various phospholipase A2s in malaria PMID: 15211007
    24. group VIA phospholipase A2 has a role in spermatozoa motility and male fertility PMID: 15252026
    25. macrophage sPLA2 IIa is a proatherogenic factor and regulates collagen production in the plaque PMID: 15576846
    26. the neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2A PMID: 15927955
    27. detected low levels of enzyme activity in inbred strains containing sPLA2-IIA mutations; these strains were also associated with greater numbers of intestinal polyps PMID: 16007193
    28. the membranes of apoptotic cells become susceptible to sPLA(2) through a reduction in lipid-neighbor interactions that facilitates migration of phospholipids into the enzyme active site PMID: 17545239
    29. Current knowledge about the various links of sPLA2-IIA to cancer of the gastro-intestinal tract, and several models to illustrate its putative biological effects on tumor development.[REVIEW] PMID: 18508504
    30. Pla2g2a plays an important role, along with Muc2, in protection of the intestinal mucosa PMID: 19037975
    31. Interval and composite interval mapping along with permutation testing identified five significant susceptibility quantitative trait loci (QTLs) responsible for radiation induced tumour multiplicity in the small intestine. PMID: 19194513
    32. Results demonstrate that Pla2g2a attenuates colon tumorigenesis independent of Apc-germline mutations PMID: 19759415

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  • 亞細(xì)胞定位：
    Secreted. Cell membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein.
  • 蛋白家族：
    Phospholipase A2 family
  • 組織特異性：
    Mainly in the Paneth cells adjacent to the stem population in the small intestines.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:18780

    UniGene: Mm.4675