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  4. Recombinant Mouse Regulating synaptic membrane exocytosis protein 1 (Rims1), partial

Recombinant Mouse Regulating synaptic membrane exocytosis protein 1 (Rims1), partial

  • 中文名稱：
    小鼠Rims1重組蛋白
  • 貨號：
    CSB-YP859997MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rims1重組蛋白
  • 貨號：
    CSB-EP859997MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rims1重組蛋白
  • 貨號：
    CSB-EP859997MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rims1重組蛋白
  • 貨號：
    CSB-BP859997MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rims1重組蛋白
  • 貨號：
    CSB-MP859997MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rims1; Kiaa0340; Rab3ip1; Rim1; Regulating synaptic membrane exocytosis protein 1; Rab-3-interacting molecule 1; RIM 1; Rab-3-interacting protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.
  • 基因功能參考文獻：
    1. Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking. PMID: 29891949
    2. Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2. PMID: 28673385
    3. RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. PMID: 27537484
    4. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47. PMID: 28377503
    5. The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel. PMID: 26400943
    6. Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking PMID: 25343783
    7. RIM1alpha can influence short-term plasticity at cerebellar parallel-fibre synapses. PMID: 23999086
    8. betaARs couple to a cAMP/Epac/PLC/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate release at cerebrocortical nerve terminals. PMID: 24036110
    9. RIM1alpha has a role in synaptic vesicle tethering. PMID: 23712261
    10. Presynaptic plasticity and function of RIM1a play an important part in the neuron's adaptive response to aberrant electrical activity following pharmacologically induced status epielepticus. PMID: 22956829
    11. The interaction between RIM1alpha and Munc13-1 is required for presynaptic long-term plasticity PMID: 21849565
    12. Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2)+ channel density and vesicle docking at the active zone. PMID: 21262468
    13. In addition to RIM1alpha's involvement in multiple behavioral abnormalities, these data suggest that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating. PMID: 20392954
    14. RIM1alpha interacts with several active zone molecules, including Munc13-1 and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal. PMID: 11797009
    15. required for presynaptic long-term potentiation. PMID: 11797010
    16. Results suggest that protein kinase A-mediated phosphorylation of the active zone protein RIM1alpha at a single N-terminal site induces presynaptic long-term potentiation. PMID: 14532002
    17. Mice with a synaptotagmin 1 mutation, which lowers release probability, and mice with Rab3A deletion, which abolishes presynaptic long-term potentiation, the combination of presynaptic abnormalities in RIM1alpha mice severely alters learning and memory. PMID: 15066271
    18. Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2 PMID: 16704978
    19. These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis. PMID: 17124501
    20. A possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested. PMID: 17237123
    21. Proteasome-mediated regulation of RIM1 and synaptic transmission is mediated by SCRAPPER (synapse localized E3 ubiquitin ligase). PMID: 17803915
    22. this difference in exploratory behavior correlated with genotype specific changes in rapid eye movement and deregulated release of norepinephrine in the cortex and basal amygdala of the Rim1 alpha knockout mice PMID: 18495360
    23. Demonstrate that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels. PMID: 18690027
    24. phosphorylation of serine-413 of RIM1alpha is not essential for PKA-dependent long-term presynaptic plasticity in vivo, suggesting that PKA operates by a different mechanism despite the dependence of long-term presynaptic plasticity on RIM1alpha PMID: 18799741
    25. These results reveal the molecular mechanisms underlying the induction of presynaptic LTP at cortico-LA synapses and indicate that RIM1alpha-dependent LTP may involve changes in Ca(2+)-release coupling. PMID: 18815362
    26. the RIM1 gene encodes two different isoforms that perform overlapping but distinct functions in neurotransmitter release PMID: 19074017

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:116837

    UniGene: Mm.380549