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  4. Recombinant Mouse Retinoblastoma-associated protein (Rb1), partial

Recombinant Mouse Retinoblastoma-associated protein (Rb1), partial

  • 中文名稱：
    小鼠Rb1重組蛋白
  • 貨號：
    CSB-YP019386MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rb1重組蛋白
  • 貨號：
    CSB-EP019386MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rb1重組蛋白
  • 貨號：
    CSB-EP019386MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rb1重組蛋白
  • 貨號：
    CSB-BP019386MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rb1重組蛋白
  • 貨號：
    CSB-MP019386MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rb1; Rb-1; Retinoblastoma-associated protein; p110-RB1; pRb; Rb; pp105
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex.
  • 基因功能參考文獻(xiàn)：
    1. The Rb1 tumor suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression. PMID: 28169375
    2. These findings demonstrate that developmental stage-specific as well as species- and cell type-specific features sensitize to RB1 inactivation and reveal the human cone precursors' capacity to model retinoblastoma initiation, proliferation, premalignant arrest, and tumor growth. PMID: 30213853
    3. Thus, Lin37 is an essential component of DREAM complex that cooperates with Rb to induce quiescence. PMID: 28920576
    4. Results show that ablation of the three members of the retinoblastoma family (RB1, p107 and p130) which targets a variety of adult lung epithelial cells, leads to spontaneous velopment of tumorlets, benign precancerous neuroendocrine (NE) lesions that do not progress to malignant tumors. Data imply the requirement of other oncogenic signaling pathways for full transformation in NE lung lesions mutant for the Rb family. PMID: 27966456
    5. studies demonstrate that pRb loss in the Tie2-lineage that includes aortic valve interstitial cells is sufficient to cause age-dependent aortic valve dysfunction PMID: 29304157
    6. These results demonstrate a crucial role for RB in the generation and the survival of DGCs in the embryonic and the adult brain. PMID: 27325572
    7. Rb selectively inhibits innate IFN-beta production by enhancing deacetylation of Ifnb1 promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases. PMID: 27267461
    8. Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice. PMID: 28343662
    9. Findings indicate that inactivation of the Rb family proteins (Rb, p107, and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO) HSCs. PMID: 28550162
    10. Combined deletion of Vhl, Trp53 and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma. PMID: 28553932
    11. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 to diverse repeat sequences. PMID: 27889452
    12. The N-Terminal phosphorylation of RB by p38 bypasses its inactivation by cyclin-dependent kinases and prevents proliferation in cancer cells. PMID: 27642049
    13. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 inhibitors releases Rb-mediated mTORC2 suppression. This, in turn, leads to elevated Akt activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt inhibitors. PMID: 27237051
    14. The data presented here support a hypothesis in which RB1 and TP53 loss in prostate cancer derepresses Ezh2 and Sox2 factors, creating a stem cell-like epigenetic environment permissive for lineage plasticity PMID: 28059767
    15. Findings reveal that Rb deficiency accelerated urinary bladder cancer progression, exposing an important role of Rb in suppressing urinary bladder cancer for treatment in the future. PMID: 28259945
    16. systems-level control of cell cycle arrest by pRB-E2F and p27-CDK regulation, is reported. PMID: 27821477
    17. RB is necessary for the recruitment of the BRG1 ATPase to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination PMID: 27940962
    18. Findings implicate Rb1 in the regulation of the THO ribonucleoprotein complex. PMID: 27001308
    19. contribution of these precursors to the Rb(+/-) adipose phenotype is driven, at least in part, by interaction with BMP7 pathway PMID: 26727985
    20. Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy. PMID: 27056896
    21. These findings establish that Rb1 and Skp2 deletions are synthetic lethal and suggest how this lethal relationship might be circumvented, which could help design better therapies for pRb-deficient cancer. PMID: 26966181
    22. Results indicate that Rb and p53 not only function as tumor suppressors in response to carcinogenic injury, but also in response to non-carcinogenic injury. PMID: 26967735
    23. Suggest that a principal role for RB1 in development is coordinating the events required for terminal differentiation of erythroid cells. PMID: 26397180
    24. data also suggest that Rb1 loss is not sufficient to transform post-germinal center B cells and that additional, specific mutations are likely required to cooperate with Rb1 loss to induce malignant transformation. PMID: 26607597
    25. Data (including data from studies in knockout/transgenic mice) suggest CDKN1B-RB1-E2F1 (cyclin-dependent kinase inhibitor 1B-RB1-E2F transcription 1) pathway is essential for SSC (spermatogonial stem cell) self-renewal/protection against DNA damage. PMID: 25959802
    26. A model suited to determine the cellular function of the alternative Rb1 transcript. PMID: 26275142
    27. we have discovered a novel role of Rb1 in regulating the entry of primordial oocytes into the pool of growing follicles and signaling between the oocyte and granulosa cells during the protracted process of oocyte growth PMID: 26176933
    28. Data show that the p16/CDKN2A-cyclin-dependent kinase 4 (CDK4)-RB1 protein pathway is frequently disrupted in fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP). PMID: 25852058
    29. the genetic interaction between Rb and p53 is a critical determinant of the undifferentiated state in normal and tumor cells. PMID: 25694388
    30. silencing of Rb enhances mitochondrial oxidative metabolism and fatty acid and glucose disposal in skeletal myotubes PMID: 26241807
    31. Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. PMID: 25745996
    32. The functions of Rb in modulating cell proliferation, death and transformation are mediated by its controlling cellular redox state. PMID: 25019272
    33. Deletion of Rb or p130 leads to impaired repression of Sox2, a defect amplified by inactivation of p53. Identify binding of pRb and p130 to an enhancer with crucial regulatory activity on Sox2 expression. PMID: 25576924
    34. protein changes induced by Rb loss are coupled with proliferation but uncoupled from transcription. PMID: 26314710
    35. Knockdown or deletion of Rb1 enhanced adult nerve regeneration after both crush and transection injuries. Plasticity is achieved in part through upregulation of neuronal PPARg. PMID: 24752312
    36. These studies therefore identify Rb as a global transcriptional repressor of pluripotency networks. PMID: 25467916
    37. Cyclin D has a role in activating the Rb tumor suppressor by mono-phosphorylation PMID: 24876129
    38. We found a central role of Rb in the dual effects of GLP-1 in alpha and beta cells. Our findings highlight unique contributions of individual Rb family members to islet cell proliferation and survival. PMID: 25249236
    39. Our data show that Rb1 mRNA is expressed in both dental epithelial and dental mesenchymal progenitor cells. In addition, Rb1 mRNA appears upregulated in differentiating ameloblasts and odontoblasts, suggesting roles for Rb1 in tooth differentiation. PMID: 22300525
    40. RESULTS: A common Rb1 allele derived from the BALB/cHeNhg strain was identified as the major determinant of radiation-induced osteosarcoma risk at this locus. PMID: 25092376
    41. Retinoblastoma protein potentiates the innate immune response in hepatocytes. PMID: 24824777
    42. Data show that phosphorylation of p27Kip1 threonine 187 (p27T187) is important in retinoblastoma protein Rb1-deficient tumorigenesis and immunity in aging. PMID: 25583987
    43. These results point to RB as a key regulator of SC function in adult mice and that the RB/E2F3 pathway directs SC maturation, cell cycle quiescence, and RB protects SC from apoptosis. PMID: 24901045
    44. The prolonged half-life of retinoblastoma 1 mRNA level secures the protein level of retinoblastoma, which facilitates cell cycle arrest of neurons in the process of ischemia/reperfusion treated with berberine. PMID: 24603897
    45. These data demonstrate the context specificity of RB and the key role RB plays in the suppression of hepatocellular carcinoma driven by xenobiotic stress. PMID: 24726645
    46. showed that the D326V missense pRb bound to E2F1 but failed to interact with E2F2/3 PMID: 25088905
    47. p21, in conjunction with pRb, has a central role in regulating multiple epithelial processes and orchestrating specific tumor suppressor functions PMID: 24121270
    48. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor target genes and allows pRb activity to be effectively integrated with the DNA damage response. PMID: 25049398
    49. In Rb1-deficient pituitary tumorigenesis, Skp2 deletion or p27T187A mutation converts E2F1's role from proliferative to apoptotic. PMID: 24632684
    50. Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PMID: 24324613

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Retinoblastoma protein (RB) family
  • 組織特異性：
    Expressed in the cell nuclei of renal tubules, hepatocytes and skeletal muscles. Expressed in skin (at protein level).
  • 數(shù)據(jù)庫鏈接：