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  4. Recombinant Mouse Rho-guanine nucleotide exchange factor (Rgnef), partial

Recombinant Mouse Rho-guanine nucleotide exchange factor (Rgnef), partial

  • 中文名稱：
    Recombinant Mouse Rho-guanine nucleotide exchange factor(Rgnef) ,partial
  • 貨號(hào)：
    CSB-YP308754MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Rho-guanine nucleotide exchange factor(Rgnef) ,partial
  • 貨號(hào)：
    CSB-EP308754MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Rho-guanine nucleotide exchange factor(Rgnef) ,partial
  • 貨號(hào)：
    CSB-EP308754MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Rho-guanine nucleotide exchange factor(Rgnef) ,partial
  • 貨號(hào)：
    CSB-BP308754MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Rho-guanine nucleotide exchange factor(Rgnef) ,partial
  • 貨號(hào)：
    CSB-MP308754MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Arhgef28
  • Uniprot No.：
  • 別名：
    Arhgef28; Kiaa1998; Rgnef; Rhoip2; Rip2; Rho guanine nucleotide exchange factor 28; 190 kDa guanine nucleotide exchange factor; p190-RhoGEF; p190RhoGEF; Rho guanine nucleotide exchange factor; Rho-interacting protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
  • 基因功能參考文獻(xiàn)：
    1. observed that the expression of RGNEF is upregulated in murine spinal motor neurons following distal sciatic nerve injury PMID: 28495450
    2. Rgnef promotes integrin beta 1-stimulated focal adhesion kinase activation. PMID: 24006257
    3. An essential role for Rgnef in RhoA regulation downstream of integrins in control of cell migration. PMID: 22649559
    4. changes in cytoskeletal tension mediated by Rho signaling through ROCK may play an important role in the establishment of the spatial differentials in cell growth and extracellular matrix remodeling that drive embryonic lung development PMID: 15614768
    5. STAT3 represents an essential effector pathway of Rho GTPases in regulating multiple cellular functions including actin cytoskeleton reorganization, cell migration, gene activation, and proliferation PMID: 15705584

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane. Note=Colocalizes with the microtubule radial and cortical systems.
  • 組織特異性：
    Highly enriched in the brain (at protein level). Also detected in lung and kidney.
  • 數(shù)據(jù)庫鏈接：