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  4. Recombinant Mouse Serine hydroxymethyltransferase, cytosolic (Shmt1)

Recombinant Mouse Serine hydroxymethyltransferase, cytosolic (Shmt1)

  • 中文名稱：
    小鼠Shmt1重組蛋白
  • 貨號：
    CSB-YP021272MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Shmt1重組蛋白
  • 貨號：
    CSB-EP021272MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Shmt1重組蛋白
  • 貨號：
    CSB-EP021272MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Shmt1重組蛋白
  • 貨號：
    CSB-BP021272MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Shmt1重組蛋白
  • 貨號：
    CSB-MP021272MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Shmt1
  • Uniprot No.：
  • 別名：
    Shmt1; ShmtSerine hydroxymethyltransferase; cytosolic; SHMT; EC 2.1.2.1; Glycine hydroxymethyltransferase; Serine methylase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-478
  • 氨基酸序列
    MADRDATLWA SHEKMLSQPL KDSDAEVYSI IKKESNRQRV GLELIASENF ASRAVLEALG SCLNNKYSEG YPGQRYYGGT EFIDELEMLC QKRALQAYHL DPQCWGVNVQ PYSGSPANFA VYTALVEPHG RIMGLDLPDG GHLTHGFMTD KKKISATSIF FESMPYKVYP ETGYINYDQL EENASLFHPK LIIAGTSCYS RNLDYARLRK IADDNGAYLM ADMAHISGLV AAGVVPSPFE HCHVVTTTTH KTLRGCRAGM IFYRKGVRSV DPKTGKETYY ELESLINSAV FPGLQGGPHN HAIAGVAVAL KQAMTTEFKI YQLQVLANCR ALSDALTELG YKIVTGGSDN HLILMDLRSK GTDGGRAEKV LEACSIACNK NTCPGDKSAL RPSGLRLGTP ALTSRGLLEE DFQKVAHFIH RGIELTLQIQ SHMATKATLK EFKEKLAGDE KIQSAVATLR EEVENFASNF SLPGLPDF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Interconversion of serine and glycine.
  • 基因功能參考文獻：
    1. Shmt1 and dietary folate deficiency influence metabolic markers of homocysteine remethylation in mice. PMID: 23700346
    2. SHMT1 and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA PMID: 22057276
    3. Data show that Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc(min)(/+) mice through a gene-by-diet interaction. PMID: 21406397
    4. These results provide evidence that disruption of Shmt1 expression causes NTDs by impairing thymidylate biosynthesis and shows that changes in the expression of genes that encode folate-dependent enzymes may be key determinates of NTD risk. PMID: 21346092
    5. It is one of the genetic components regulating PPI in mice and is relevant to schizophrenia susceptibility in humans. (review) PMID: 21226315
    6. Shmt1 (SHMT1), but not Srr, is likely to be one of the genetic components regulating prepulse inhibition in mice and possibly relevant to human schizophrenia. PMID: 20977478
    7. mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm PMID: 18644786
    8. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis PMID: 19513116

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    SHMT family
  • 數(shù)據(jù)庫鏈接：