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  4. Recombinant Mouse Serine-protein kinase ATM (Atm), partial

Recombinant Mouse Serine-protein kinase ATM (Atm), partial

  • 中文名稱：
    Recombinant Mouse Serine-protein kinase ATM(Atm) ,partial
  • 貨號：
    CSB-YP726793MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Serine-protein kinase ATM(Atm) ,partial
  • 貨號：
    CSB-EP726793MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Serine-protein kinase ATM(Atm) ,partial
  • 貨號：
    CSB-EP726793MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Serine-protein kinase ATM(Atm) ,partial
  • 貨號：
    CSB-BP726793MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Serine-protein kinase ATM(Atm) ,partial
  • 貨號：
    CSB-MP726793MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    AtmSerine-protein kinase ATM; EC 2.7.11.1; Ataxia telangiectasia mutated homolog; A-T mutated homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.
  • 基因功能參考文獻(xiàn)：
    1. SOD2 expression is ATM- and RelA-dependent, ATM knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm deletion significantly diminished the expression of Sod2. PMID: 28849346
    2. These data suggest that ATM and ATR are part of the cellular "infrastructure" that maintains the excitatory/inhibitory balance of the nervous system. PMID: 29279380
    3. ATM has a role in homology-directed repair (HDR) independent of the BRCA1-53BP1 antagonism; its HDR function can become critical in certain contexts PMID: 28659469
    4. intestinal tuft cells play an important role in regulating the ATM mediated DNA damage response, for epithelial cell survival/self-renewal via a Dclk1 dependent mechanism PMID: 27876863
    5. in the Atm(-/-) MEFs, the same Radiofrequency electromagnetic fields exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose PMID: 27857169
    6. ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure. PMID: 28724653
    7. H2AX shows a similar influence as ATM. PMID: 28057860
    8. The ATM protein is a key mediator of H2O2 preconditioning. PMID: 28487983
    9. ATM is the primary kinase responsible for phosphorylation of Hsp90alpha after exposure ionizing radiation. PMID: 27738310
    10. These findings define an antagonistic function of ATM and MAPK7 in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes. PMID: 27793024
    11. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia that can be successfully reversed. PMID: 27791036
    12. Baf60b, a member of the SWI/SNF chromatin remodeling complex, links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci. PMID: 28303890
    13. Results demonstrate that alterations in ATM levels are responsible for pronounced and anticipated GABAergic development and function. Since GABA transmission is strongly linked to the correct brain development and plasticity, this study lays basics for both a more clear comprehension of mechanisms associated with brain development. PMID: 27166172
    14. These data indicate that defective Atm reduces the redox homeostasis of the testis and genetic integrity of sperm by regulating glutathione levels independently from G6PDH activity. PMID: 27318254
    15. WSB1 is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier. PMID: 27958289
    16. Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias. PMID: 27625305
    17. Data show that Tp53- and Atm-defective Chronic lymphocytic leukemia (CLL) mimicking the high-risk form of human disease and that Atm-deficient CLL is sensitive to PARP1 inhibition. PMID: 28751718
    18. Depletion of H3K9ac in embryonic stem cells by suppression of monocytic leukemia zinc finger protein (MOZ) acetyltransferase improved ATM activation, DNA repair, diminished irradiation-induced apoptosis, and enhanced clonogenic survival. PMID: 27974220
    19. The data demonstrate ATM is important for the maintenance of telomere homeostasis and the surveillance of telomere dysfunction during neurogenesis. PMID: 28620865
    20. DNA damage induces a kinetochore-based ATM/ATR-independent spindle assembly checkpoint arrest. PMID: 28851706
    21. The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX formation, and failure to remove H2BK120ub inhibits ATM- and DNAPK-induced gammaH2AX formation. PMID: 27160905
    22. ATM expression by peritoneal B cells is required to facilitate viral reactivation during long-term infection. Thus, this study defines a proviral role of B cell-specific ATM expression during chronic gammaherpesvirus infection. PMID: 28701397
    23. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways. PMID: 26887372
    24. this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects PMID: 27421701
    25. This study show that like ataxia telangiectasia cells, ISG15 is elevated in Atm-deficient mouse cerebellums. PMID: 28535250
    26. This study identifies attenuation of type I interferon responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection. PMID: 28732227
    27. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2. PMID: 27424808
    28. USP7 inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 and synergizes with chemotherapy. PMID: 28495793
    29. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53/Atm-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 in response to prolonged exposure to IR. PMID: 27758128
    30. ATM, ATR and DNA-PKcs have unique and essential roles during the DNA damage response in the nervous system. PMID: 28123024
    31. TRAF6 and H2AX overexpression and gammaH2AX-mediated HIF1alpha enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha-driven tumorigenesis, glycolysis and metastasis. PMID: 27918549
    32. These results reveal a new requirement for ATMIN-dependent ATM signaling in TP53-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors. PMID: 26984279
    33. results demonstrate that even low-dose IR results in ATM activation. In the absence of ATM, low-dose IR leads to increased inflammation, oxidative stress and lethality in the Atm-deficient mouse model. PMID: 26752140
    34. Findings indicate that miR-302b plays a relevant role in breast cancer cell response to cisplatin through the modulation of the E2F1 transcription factor (E2F1)/ataxia telangiectasia mutated protein (ATM) axis. PMID: 26623722
    35. study highlights using rodent models and human subjects, the critical role of ATM in microvascular repair in DR. PMID: 26502796
    36. Cerebellar astroglia isolated from Atm mutant mice show decreased expression of the cystine/glutamate exchanger subunit xCT, glutathione reductase, and glutathione-S-transferase PMID: 26469940
    37. Authors generated an inducible Atm mutant mouse model (Atm(tm1Mmpl/tm1Mmpl), referred to as A-T [M]) predicted to express only the first 62 amino acids of Atm PMID: 26310626
    38. ATM-BID-MTCH2 pathway that we have identified plays a critical role in the DDR via regulation of mitochondrial metabolism. PMID: 26611459
    39. TRAX is required for DNA repair, by interacting with activated ATM and protects cells from genotoxic stress-induced apoptosis. PMID: 26096928
    40. ATM facilitates restriction of signal ends to the classical nonhomologous end-joining pathway. PMID: 26921311
    41. TET1-mediated 5hmC production is linked to the degenerative process of Purkinje cells and behavioural deficits in Atm(-/-) mice. Taken together, the selective loss of 5hmC plays a critical role in driving Purkinje cell vulnerability in ATM deficiency PMID: 26510954
    42. The authors demonstrate that ATM can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50-NBS1 (MRN) sensor complex. PMID: 26280532
    43. Loss of ATM in pancreatic ductal adenocarcinoma enhances acinar-to-ductal reprogramming via altered TGFbeta-superfamily signalling and is associated with epithelial-to-mesenchymal transition and a gain in tumor initiating properties. PMID: 26220524
    44. This study reveals that ATM protects against development of B-cell lymphomas that model human ABC DLBCL and identifies a potential role for T cells in preventing the emergence of these tumors. PMID: 26400962
    45. Inhibition of ATM kinase decreased manganese-dependent phosphorylation of p53. PMID: 25489053
    46. TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2 PMID: 25768017
    47. Cyclin D3 protein that drives immature T cell proliferation is essential for transformation of Atm-deficient thymocytes PMID: 25659036
    48. Myeloid-specific ATM deficiency attenuated gammaherpesvirus infection during the establishment of viral latency. PMID: 26001649
    49. ATM deficiency results in decreased dilative remodeling and delays inflammatory response acute post-myocardial infarction. However, it associates with increased fibrosis and apoptosis. PMID: 25520329
    50. Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas . PMID: 25676421

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    PI3/PI4-kinase family, ATM subfamily
  • 組織特異性：
    Expressed in brain, skeletal muscle, testis, followed by spleen, lung, kidney, heart, liver and thymus. Ubiquitously expressed in embryonal tissues.
  • 數(shù)據(jù)庫鏈接：