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  4. Recombinant Mouse Stanniocalcin-2 (Stc2)

Recombinant Mouse Stanniocalcin-2 (Stc2)

In Stock
  • 中文名稱：
    小鼠Stc2重組蛋白
  • 貨號：
    CSB-EP022822MO
  • 規(guī)格：
    ￥3324
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Stc2; Stanniocalcin-2; STC-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    30.1 kDa
  • 表達(dá)區(qū)域：
    25-296aa
  • 氨基酸序列
    TDSTNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIQGLHGICMTFLHNAGKFDAQGKSFIKDALRCKAHALRHKFGCISRKCPAIREMVFQLQRECYLKHDLCSAAQENVGVIVEMIHFKDLLLHEPYVDLVNLLLTCGEDVKEAVTRSVQAQCEQSWGGLCSILSFCTSNIQRPPTAAPEHQPLADRAQLSRPHHRDTDHHLTANRGAKGERGSKSHPNAHARGRTGGQSAQGPSGSSEWEDEQSEYSDIRR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    Tag-Free
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
  • 基因功能參考文獻(xiàn)：
    1. results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation PMID: 28696214
    2. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    3. Stanniocalcin-2 inhibits proteolytic release of IGF and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function. PMID: 25533459
    4. The Stc2 promoter contains multiple putative xenobiotic response elements. PMID: 23269473
    5. These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho-Fgf23 signaling may contribute to limitation of ectopic calcification. PMID: 22285620
    6. These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2+ homeostasis by mammalian STC2. PMID: 21746875
    7. STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury. PMID: 21545732
    8. induced STC2 expression is an essential feature of survival component of the unfolded-protein response PMID: 15485913
    9. The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. PMID: 18258678

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Stanniocalcin family
  • 組織特異性：
    Found in a variety of tissues including skeletal muscle, small intestine, kidney, liver and brain.
  • 數(shù)據(jù)庫鏈接：