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  4. Recombinant Mouse Transferrin receptor protein 2 (Tfr2), partial

Recombinant Mouse Transferrin receptor protein 2 (Tfr2), partial

In Stock
  • 中文名稱：
    小鼠Tfr2重組蛋白
  • 貨號(hào)：
    CSB-MP878096MO
  • 規(guī)格：
    ￥1908
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    TfR2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    104.6 kDa
  • 表達(dá)區(qū)域：
    103-798aa
  • 氨基酸序列
    RGSCQACGDSVLVVDEDVNPEDSGRTTLYWSDLQAMFLRFLGEGRMEDTIRLTSLRERVAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHANTLHWVDADGSVQEQLPLEDPEVYCPYSATGNATGKLVYAHYGRSEDLQDLKAKGVELAGSLLLVRVGITSFAQKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGLSSHQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVESSGLPSIPAQPISADIADQLLRKLTGPVAPQEWKGHLSGSPYRLGPGPDLRLVVNNHRVSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLGDGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDSSAYSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVQAVAQLAGQLLIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKERGLTLQWVYSARGDYIRAAEKLRKEIYSSERNDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALVDHLRMLRADGSGAASSRLTAGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal mFc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
  • 基因功能參考文獻(xiàn)：
    1. Tfr2 is a key regulator of brain iron homeostasis and propose a role for Tfr2 alpha in the regulation of anxiety circuits. PMID: 27477597
    2. these data confirm the role of Tfr2a in modulation of erythropoiesis and of Tfr2b in favoring iron availability for erythropoiesis PMID: 28540293
    3. erythroid Tfr2 is essential for an appropriate erythropoietic response in iron-deficient anemia PMID: 27169626
    4. These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin and thus macrophage iron homeostasis PMID: 26608187
    5. Tfr2 is a novel target gene for HNF4alpha, and hepatic HNF4alpha plays a critical role in iron homeostasis. PMID: 26527688
    6. There is an essential role for TFR2 in erythropoiesis that may provide new targets for the treatment of anaemia. PMID: 25403101
    7. We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo sensitivity. PMID: 25499454
    8. We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction. PMID: 24658816
    9. These results support in vivo studies which suggest that Hfe and Tfr2 can independently regulate hepcidin. PMID: 24155934
    10. we used microarray and real-time reverse transcription polymerase chain reaction to assess brain transcriptome profiles of transferrin receptor 2 mutant mice a model of a rare type of hereditary hemochromatosis PMID: 23333676
    11. Double mutant mice lacking functional Hfe or Tfr2 and Tmprss6 exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 demonstrating that Hfe and Tfr2 are not substrates for Tmprss6. PMID: 22244935
    12. Disruption of both Hfe and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone. PMID: 22383097
    13. Tfr2 is not essential for Hfe-mediated induction of hepcidin expression, supporting the possibility that TFR2 may regulate iron metabolism in an HFE-independent manner. PMID: 22460705
    14. that TfR2 exhibits a non hepatic function as a component of the EpoR complex and is required for efficient erythropoiesis. PMID: 20826723
    15. A small reduction in hepatic transferrin-bound iron uptake in Tfr2 mutant mice suggests that Tfr2 plays a minor role in liver iron transport and its primary role is to regulate iron metabolism. PMID: 20133002
    16. Our results strengthen the function of hepatic alpha-Tfr2 in hepcidin activation, suggest a role for extrahepatic Tfr2 and indicate that beta-Tfr2 may specifically control spleen iron efflux. PMID: 20179178
    17. Hfe is limiting in formation of the Hfe/Tfr2 complex that regulates hepcidin expression PMID: 20177050
    18. targeted mutagenesis of the murine transferrin receptor 2 gene produces hemochromatosis PMID: 12134060
    19. role of TfR2 in iron metabolism PMID: 15124225
    20. Tfr2 deficient mice react normally to endotoxin and their hepatocytes react normally to IL-6. PMID: 15192150
    21. TfR2 acts as a sensor of iron status such that receptor levels reflect transferrin saturation. PMID: 15319276
    22. up-regulation of hepcidin expression by inflammatory stimuli is independent of TfR2 and that TfR2 is upstream of hepcidin in the regulatory pathway of body iron homeostasis PMID: 15345587
    23. TfR2 is a sensor of iron status and regulates duodenal iron absorption and liver Fe uptake. PMID: 16935854
    24. the liver is the primary site for TfR2 expression and activity and liver-expressed TfR2 is required for the regulation of hepcidin1 PMID: 17241880
    25. Our results indicate that the majority of mutations that cause type 3 hereditary hemochromatosis are a consequence of the defective localization of the TFR2 protein. PMID: 18094142
    26. These data confirm the cytoprotective function of Tf, and show that both apoptotic Fas responses and cytoprotective effects of Tf were associated with shifts in plasma iron levels, which differed between male and female mice. PMID: 18561026
    27. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. PMID: 19824072

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cytoplasm.
  • 蛋白家族：
    Peptidase M28 family, M28B subfamily
  • 組織特異性：
    Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart.
  • 數(shù)據(jù)庫鏈接：