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Recombinant Naja kaouthia Alpha-cobratoxin

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  • 中文名稱：
    Recombinant Naja kaouthia Alpha-cobratoxin
  • 貨號：
    CSB-EP365543NAF
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    Alpha-cobratoxin; Alpha-CbT; alpha-CT; alpha-Cbtx; Alpha-elapitoxin-Nk2a; Alpha-EPTX-Nk2a; Long neurotoxin 1; Siamensis 3
  • 種屬：
    Naja kaouthia (Monocled cobra) (Naja siamensis)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    37.8 kDa
  • 表達區(qū)域：
    1-71aa
  • 氨基酸序列
    IRCFITPDITSKDCPNGHVCYTKTWCDAFCSIRGKRVDLGCAATCPTVKTGVDIQCCSTDNCNPFPTRKRP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    The recombinant Naja kaouthia Alpha-CT protein is encoded by the gene of Alpha-CT (1-71aa). The gene of Alpha-CT was cloned in a system (E.coli) that supported the expression of Alpha-CT. Modification of Alpha-CT by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 10xHis-GST tag & C-terminal Myc tag in the production. The purity is 85% determined by SDS-PAGE.

    Alpha-cobratoxin is a nicotinic acetylcholine receptor. According to some research, Alpha-cobratoxin may have the following features.
    Alpha-cobratoxin as a possible treatment for multiple sclerosis. Alpha-cobratoxin inhibits the T-type calcium current of dorsal root ganglion neurons through the muscarinic M4 receptor and Go-protein βγ subunit-dependent protein kinase A pathway. Isolation and characterization of high-affinity VHH antibody fragments against alpha-cobratoxin.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA).; Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs.; Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily
  • 組織特異性：
    Expressed by the venom gland.